Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.8.1.14 extracted from

  • van der Westhuyzen, R.; Strauss, E.
    Michael acceptor-containing coenzyme A analogues as inhibitors of the atypical coenzyme A disulfide reductase from Staphylococcus aureus (2010), J. Am. Chem. Soc., 132, 12853-12855.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
(E)-2-(methylsulfonyl)ethenyl-CoA competitive inhibition Staphylococcus aureus
(E)-2-(phenylsulfonyl)ethenyl-CoA competitive inhibition Staphylococcus aureus
ethyl (2E)-prop-2-en-3-CoA-oate competitive inhibition Staphylococcus aureus
t-butyl (2E)-prop-2-en-3-CoA-oate competitive inhibition Staphylococcus aureus

Organism

Organism UniProt Comment Textmining
Staphylococcus aureus
-
-
-

Synonyms

Synonyms Comment Organism
CoADR
-
Staphylococcus aureus
coenzyme A disulfide reductase
-
Staphylococcus aureus

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Staphylococcus aureus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00004
-
(E)-2-(phenylsulfonyl)ethenyl-CoA temperature not specified in the publication, in 20 mM Tris-HCl, pH 7.4 Staphylococcus aureus
0.0003
-
(E)-2-(methylsulfonyl)ethenyl-CoA temperature not specified in the publication, in 20 mM Tris-HCl, pH 7.4 Staphylococcus aureus
0.00066
-
ethyl (2E)-prop-2-en-3-CoA-oate temperature not specified in the publication, in 20 mM Tris-HCl, pH 7.4 Staphylococcus aureus
0.00516
-
t-butyl (2E)-prop-2-en-3-CoA-oate temperature not specified in the publication, in 20 mM Tris-HCl, pH 7.4 Staphylococcus aureus