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Literature summary for 1.8.1.12 extracted from

  • Rodriguez-Becerra, J.; Caceres-Jensen, L.; Hernandez-Ramos, J.; Barrientos, L.
    Identification of potential trypanothione reductase inhibitors among commercially available beta-carboline derivatives using chemical space, lead-like and drug-like filters, pharmacophore models and molecular docking (2017), Mol. Divers., 21, 697-711 .
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Trypanosoma cruzi P28593
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-

Synonyms

Synonyms Comment Organism
trypanothione reductase
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Trypanosoma cruzi

General Information

General Information Comment Organism
drug target trypanothione (N1,N8-bis(glutathyonil)spermidine) and trypanothione reductase, which are rather unique to trypanosomes and completely absent in mammalian cells Trypanosoma cruzi