Literature summary for 1.8.1.12 extracted from

Rodrigues, R.F.; Castro-Pinto, D.; Echevarria, A.; dos Reis, C.M.; Del Cistia, C.N.; SantAnna, C.M.; Teixeira, F.; Castro, H.; Canto-Cavalheiro, M.; Leon, L.L.; Tomas, A.
Investigation of trypanothione reductase inhibitory activity by 1,3,4-thiadiazolium-2-aminide derivatives and molecular docking studies (2012), Bioorg. Med. Chem., 20, 1760-1766.

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Inhibitors

Inhibitors	Comment	Organism	Structure
2-[(E)-2-(4-nitrophenyl)ethenyl]-3-phenyl-5-(phenylamino)-2,5-dihydro-1,3,4-thiadiazol-3-ium chloride	non-competitive inhibition, 76% inhibition at 0.001 mM	Leishmania amazonensis
2-[(E)-2-(4-nitrophenyl)ethenyl]-3-phenyl-5-(phenylamino)-2,5-dihydro-1,3,4-thiadiazol-3-ium chloride	non-competitive inhibition, 69.5% inhibition at 0.001 mM	Leishmania braziliensis
2-[(E)-2-(4-nitrophenyl)ethenyl]-3-phenyl-5-(phenylamino)-2,5-dihydro-1,3,4-thiadiazol-3-ium chloride	non-competitive inhibition, 70% inhibition at 0.001 mM	Leishmania infantum
2-[(E)-2-(4-nitrophenyl)ethenyl]-3-phenyl-5-(phenylamino)-2,5-dihydro-1,3,4-thiadiazol-3-ium chloride	non-competitive inhibition, 83% inhibition at 0.001 mM	Trypanosoma cruzi

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
trypanothione disulfide + NADPH + H+	Trypanosoma cruzi	-	trypanothione + NADP+	-	?
trypanothione disulfide + NADPH + H+	Leishmania amazonensis	-	trypanothione + NADP+	-	?
trypanothione disulfide + NADPH + H+	Leishmania infantum	-	trypanothione + NADP+	-	?
trypanothione disulfide + NADPH + H+	Leishmania braziliensis	-	trypanothione + NADP+	-	?
trypanothione disulfide + NADPH + H+	Trypanosoma cruzi Y	-	trypanothione + NADP+	-	?
trypanothione disulfide + NADPH + H+	Leishmania amazonensis MHOM/BR/LTB0016	-	trypanothione + NADP+	-	?
trypanothione disulfide + NADPH + H+	Leishmania infantum MHOM/MA67ITMAP263	-	trypanothione + NADP+	-	?
trypanothione disulfide + NADPH + H+	Leishmania braziliensis MCAN/BR/98/R619	-	trypanothione + NADP+	-	?

Organism

Organism	UniProt	Comment	Textmining
Leishmania amazonensis	-	-	-
Leishmania amazonensis MHOM/BR/LTB0016	-	-	-
Leishmania braziliensis	-	-	-
Leishmania braziliensis MCAN/BR/98/R619	-	-	-
Leishmania infantum	-	-	-
Leishmania infantum MHOM/MA67ITMAP263	-	-	-
Trypanosoma cruzi	-	-	-
Trypanosoma cruzi Y	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
epimastigote	-	Trypanosoma cruzi	-
epimastigote	-	Leishmania amazonensis	-
epimastigote	-	Leishmania infantum	-
epimastigote	-	Leishmania braziliensis	-
promastigote	-	Trypanosoma cruzi	-
promastigote	-	Leishmania amazonensis	-
promastigote	-	Leishmania infantum	-
promastigote	-	Leishmania braziliensis	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
trypanothione disulfide + NADPH + H+	-	Trypanosoma cruzi	trypanothione + NADP+	-	?
trypanothione disulfide + NADPH + H+	-	Leishmania amazonensis	trypanothione + NADP+	-	?
trypanothione disulfide + NADPH + H+	-	Leishmania infantum	trypanothione + NADP+	-	?
trypanothione disulfide + NADPH + H+	-	Leishmania braziliensis	trypanothione + NADP+	-	?
trypanothione disulfide + NADPH + H+	-	Trypanosoma cruzi Y	trypanothione + NADP+	-	?
trypanothione disulfide + NADPH + H+	-	Leishmania amazonensis MHOM/BR/LTB0016	trypanothione + NADP+	-	?
trypanothione disulfide + NADPH + H+	-	Leishmania infantum MHOM/MA67ITMAP263	trypanothione + NADP+	-	?
trypanothione disulfide + NADPH + H+	-	Leishmania braziliensis MCAN/BR/98/R619	trypanothione + NADP+	-	?

Synonyms

Synonyms	Comment	Organism
trypanothione reductase	-	Trypanosoma cruzi
trypanothione reductase	-	Leishmania amazonensis
trypanothione reductase	-	Leishmania infantum
trypanothione reductase	-	Leishmania braziliensis
TryR	-	Trypanosoma cruzi
TryR	-	Leishmania amazonensis
TryR	-	Leishmania infantum
TryR	-	Leishmania braziliensis

Cofactor

Cofactor	Comment	Organism	Structure
FAD	-	Trypanosoma cruzi
FAD	-	Leishmania amazonensis
FAD	-	Leishmania infantum
FAD	-	Leishmania braziliensis
NADPH	-	Trypanosoma cruzi
NADPH	-	Leishmania amazonensis
NADPH	-	Leishmania infantum
NADPH	-	Leishmania braziliensis

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Release 2023.1 (January 2023)