Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2Z)-2-[(2E)-2-(3H-indol-3-ylidene)ethylidene]-1-methyl-1,2-dihydroquinoline | - |
Trypanosoma cruzi | |
1-(1-benzylpiperidin-4-yl)-3-phenylthiourea | - |
Trypanosoma cruzi | |
1-(1-benzylpiperidin-4-yl)-3-pyridin-3-ylthiourea | - |
Trypanosoma cruzi | |
1-(1-phenylpiperidin-4-yl)-3-propylthiourea | - |
Trypanosoma cruzi | |
1-(2-phenoxyethyl)-3-[2-(piperidin-1-yl)ethyl]-1,3-dihydro-2H-benzimidazol-2-imine | - |
Trypanosoma cruzi | |
1-(4,6,8-trimethylquinazolin-2-yl)guanidine | - |
Trypanosoma cruzi | |
1-(4-methylquinazolin-2-yl)guanidine | - |
Trypanosoma cruzi | |
1-(methylsulfanyl)-4-[3-(methylsulfanyl)-1,2,4-triazin-5-yl]-5,6,7,8-tetrahydroisoquinoline | - |
Trypanosoma cruzi | |
1-phenyl-3-(1-phenylpiperidin-4-yl)thiourea | - |
Trypanosoma cruzi | |
1-phenyl-3-[1-(pyridin-3-yl)piperidin-4-yl]urea | - |
Trypanosoma cruzi | |
3-(methylsulfanyl)-5-phenyl-1,2,4-triazine | - |
Trypanosoma cruzi | |
3-cyano-1-azabicyclo[2.2.2]oct-3-yl acetate | - |
Trypanosoma cruzi | |
3-methoxy-3'-(methylsulfanyl)-5,5'-bi-1,2,4-triazine | - |
Trypanosoma cruzi | |
4,6,8-trimethyl-N-(4,4,6-trimethyl-1,4-dihydropyrimidin-2-yl)quinazolin-2-amine | - |
Trypanosoma cruzi | |
5,6-dimethyl-2-[(4,6,8-trimethylquinazolin-2-yl)amino]pyrimidin-4-ol | - |
Trypanosoma cruzi | |
7-ethoxy-4-methyl-N-(4,4,6-trimethyl-4,5-dihydropyrimidin-2-yl)quinazolin-2-amine | - |
Trypanosoma cruzi | |
7-ethyl-4-methyl-N-(4,4,6-trimethyl-4,5-dihydropyrimidin-2-yl)quinazolin-2-amine | - |
Trypanosoma cruzi | |
ajoene | - |
Trypanosoma cruzi | |
carmustine | - |
Trypanosoma cruzi | |
Mepacrine | - |
Trypanosoma cruzi | |
N-(4,6-dimethylpyrimidin-2-yl)-4,5,7-trimethylquinazolin-2-amine | - |
Trypanosoma cruzi | |
N-(4,6-dimethylpyrimidin-2-yl)-4,6-dimethylquinazolin-2-amine | - |
Trypanosoma cruzi | |
N-[(4-chlorophenyl)(phenyl)methoxy]-8-methyl-8-azabicyclo[3.2.1]octan-3-imine | - |
Trypanosoma cruzi | |
spermidine | - |
Trypanosoma cruzi | |
spermine | - |
Trypanosoma cruzi |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0015 | - |
trypanothione disulfide | apparent value, in the presence of 0.05 mM DTNB and 0.15 mM NADPH, in 40 mM HEPES, 1 mM EDTA, 0.01% (v/v) BSA, and 0.05% (v/v) Tween 20, pH 7.5, at 22°C | Trypanosoma cruzi |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Trypanosoma cruzi | - |
- |
- |
Trypanosoma cruzi Silvio X10/1 | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
trypanothione disulfide + NADPH + H+ | - |
Trypanosoma cruzi | trypanothione + NADP+ | - |
? | |
trypanothione disulfide + NADPH + H+ | - |
Trypanosoma cruzi Silvio X10/1 | trypanothione + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
trypanothione reductase | - |
Trypanosoma cruzi |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | - |
Trypanosoma cruzi | |
NADPH | - |
Trypanosoma cruzi |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.002 | - |
in 40 mM HEPES, 1 mM EDTA, 0.01% (v/v) bovine serum albumin, 0.05% (v/v) Tween 20, pH 7.5, 22°C | Trypanosoma cruzi | 1-(1-benzylpiperidin-4-yl)-3-phenylthiourea | |
0.009 | - |
in 40 mM HEPES, 1 mM EDTA, 0.01% (v/v) bovine serum albumin, 0.05% (v/v) Tween 20, pH 7.5, 22°C | Trypanosoma cruzi | 1-(2-phenoxyethyl)-3-[2-(piperidin-1-yl)ethyl]-1,3-dihydro-2H-benzimidazol-2-imine | |
0.017 | - |
in 40 mM HEPES, 1 mM EDTA, 0.01% (v/v) bovine serum albumin, 0.05% (v/v) Tween 20, pH 7.5, 22°C | Trypanosoma cruzi | 4,6,8-trimethyl-N-(4,4,6-trimethyl-1,4-dihydropyrimidin-2-yl)quinazolin-2-amine | |
0.023 | - |
in 40 mM HEPES, 1 mM EDTA, 0.01% (v/v) bovine serum albumin, 0.05% (v/v) Tween 20, pH 7.5, 22°C | Trypanosoma cruzi | (2Z)-2-[(2E)-2-(3H-indol-3-ylidene)ethylidene]-1-methyl-1,2-dihydroquinoline | |
0.027 | - |
in 40 mM HEPES, 1 mM EDTA, 0.01% (v/v) bovine serum albumin, 0.05% (v/v) Tween 20, pH 7.5, 22°C | Trypanosoma cruzi | 3-methoxy-3'-(methylsulfanyl)-5,5'-bi-1,2,4-triazine | |
0.028 | - |
in 40 mM HEPES, 1 mM EDTA, 0.01% (v/v) bovine serum albumin, 0.05% (v/v) Tween 20, pH 7.5, 22°C | Trypanosoma cruzi | 7-ethoxy-4-methyl-N-(4,4,6-trimethyl-4,5-dihydropyrimidin-2-yl)quinazolin-2-amine | |
0.032 | - |
in 40 mM HEPES, 1 mM EDTA, 0.01% (v/v) bovine serum albumin, 0.05% (v/v) Tween 20, pH 7.5, 22°C | Trypanosoma cruzi | 7-ethyl-4-methyl-N-(4,4,6-trimethyl-4,5-dihydropyrimidin-2-yl)quinazolin-2-amine | |
0.033 | - |
in 40 mM HEPES, 1 mM EDTA, 0.01% (v/v) bovine serum albumin, 0.05% (v/v) Tween 20, pH 7.5, 22°C | Trypanosoma cruzi | N-[(4-chlorophenyl)(phenyl)methoxy]-8-methyl-8-azabicyclo[3.2.1]octan-3-imine | |
0.033 | - |
in 40 mM HEPES, 1 mM EDTA, 0.01% (v/v) bovine serum albumin, 0.05% (v/v) Tween 20, pH 7.5, 22°C | Trypanosoma cruzi | 1-phenyl-3-(1-phenylpiperidin-4-yl)thiourea | |
0.052 | - |
in 40 mM HEPES, 1 mM EDTA, 0.01% (v/v) bovine serum albumin, 0.05% (v/v) Tween 20, pH 7.5, 22°C | Trypanosoma cruzi | 3-cyano-1-azabicyclo[2.2.2]oct-3-yl acetate | |
0.1 | - |
IC50 above 0.1 mM, in 40 mM HEPES, 1 mM EDTA, 0.01% (v/v) bovine serum albumin, 0.05% (v/v) Tween 20, pH 7.5, 22°C | Trypanosoma cruzi | 1-(1-phenylpiperidin-4-yl)-3-propylthiourea | |
0.1 | - |
IC50 above 0.1 mM, in 40 mM HEPES, 1 mM EDTA, 0.01% (v/v) bovine serum albumin, 0.05% (v/v) Tween 20, pH 7.5, 22°C | Trypanosoma cruzi | 1-(1-benzylpiperidin-4-yl)-3-pyridin-3-ylthiourea | |
0.1 | - |
IC50 above 0.1 mM, in 40 mM HEPES, 1 mM EDTA, 0.01% (v/v) bovine serum albumin, 0.05% (v/v) Tween 20, pH 7.5, 22°C | Trypanosoma cruzi | 1-phenyl-3-[1-(pyridin-3-yl)piperidin-4-yl]urea | |
0.1 | - |
IC50 above 0.1 mM, in 40 mM HEPES, 1 mM EDTA, 0.01% (v/v) bovine serum albumin, 0.05% (v/v) Tween 20, pH 7.5, 22°C | Trypanosoma cruzi | 1-(methylsulfanyl)-4-[3-(methylsulfanyl)-1,2,4-triazin-5-yl]-5,6,7,8-tetrahydroisoquinoline | |
0.1 | - |
IC50 above 0.1 mM, in 40 mM HEPES, 1 mM EDTA, 0.01% (v/v) bovine serum albumin, 0.05% (v/v) Tween 20, pH 7.5, 22°C | Trypanosoma cruzi | 3-(methylsulfanyl)-5-phenyl-1,2,4-triazine | |
0.1 | - |
IC50 above 0.1 mM, in 40 mM HEPES, 1 mM EDTA, 0.01% (v/v) bovine serum albumin, 0.05% (v/v) Tween 20, pH 7.5, 22°C | Trypanosoma cruzi | 5,6-dimethyl-2-[(4,6,8-trimethylquinazolin-2-yl)amino]pyrimidin-4-ol | |
0.1 | - |
IC50 above 0.1 mM, in 40 mM HEPES, 1 mM EDTA, 0.01% (v/v) bovine serum albumin, 0.05% (v/v) Tween 20, pH 7.5, 22°C | Trypanosoma cruzi | N-(4,6-dimethylpyrimidin-2-yl)-4,5,7-trimethylquinazolin-2-amine | |
0.1 | - |
IC50 above 0.1 mM, in 40 mM HEPES, 1 mM EDTA, 0.01% (v/v) bovine serum albumin, 0.05% (v/v) Tween 20, pH 7.5, 22°C | Trypanosoma cruzi | N-(4,6-dimethylpyrimidin-2-yl)-4,6-dimethylquinazolin-2-amine | |
0.1 | - |
IC50 above 0.1 mM, in 40 mM HEPES, 1 mM EDTA, 0.01% (v/v) bovine serum albumin, 0.05% (v/v) Tween 20, pH 7.5, 22°C | Trypanosoma cruzi | 1-(4,6,8-trimethylquinazolin-2-yl)guanidine | |
0.1 | - |
IC50 above 0.1 mM, in 40 mM HEPES, 1 mM EDTA, 0.01% (v/v) bovine serum albumin, 0.05% (v/v) Tween 20, pH 7.5, 22°C | Trypanosoma cruzi | 1-(4-methylquinazolin-2-yl)guanidine |