Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(3'R,4'R)-3'-carbamoyl-1'-(2-oxo-2-[[2-(phenylsulfanyl)phenyl]amino]ethyl)-1,4'-bipiperidinium | ZINC01063940 | Trypanosoma brucei | |
(3'R,4'R)-3'-carbamoyl-1'-(2-oxo-2-[[2-(phenylsulfanyl)phenyl]amino]ethyl)-1,4'-bipiperidinium | ZINC01063940 | Trypanosoma cruzi | |
1-(2-oxo-2-[[2-(phenylsulfanyl)phenyl]amino]ethyl)-4-phenylpiperazin-1-ium | ZINC05829158 | Trypanosoma brucei | |
1-(2-oxo-2-[[2-(phenylsulfanyl)phenyl]amino]ethyl)-4-phenylpiperazin-1-ium | ZINC05829158 | Trypanosoma cruzi | |
1-(3-bromobenzyl)-5,7-dimethyl-1,3-diazoniatricyclo[3.3.1.13,7]decane | ZINC00346140 | Trypanosoma brucei | |
1-(3-bromobenzyl)-5,7-dimethyl-1,3-diazoniatricyclo[3.3.1.13,7]decane | ZINC00346140 | Trypanosoma cruzi | |
1-(4-methylphenyl)-5-oxo-N-[2-(phenylsulfanyl)phenyl]pyrrolidine-3-carboxamide | ZINC1064012 | Trypanosoma brucei | |
1-(4-methylphenyl)-5-oxo-N-[2-(phenylsulfanyl)phenyl]pyrrolidine-3-carboxamide | ZINC1064012 | Trypanosoma cruzi | |
1-(8-chloro-10,11-dihydrodibenzo[b,f]thiepin-10-yl)-4-ethylpiperazinediium | ZINC00702046 | Trypanosoma brucei | |
1-(8-chloro-10,11-dihydrodibenzo[b,f]thiepin-10-yl)-4-ethylpiperazinediium | ZINC00702046 | Trypanosoma cruzi | |
1-benzyl-4-[[(1E)-(1-cyclohexyl-2,4,6-trioxohexahydropyrimidin-5-yl)methylidene]amino]-1-methylpiperidinium | ZINC05119716 | Trypanosoma brucei | |
1-benzyl-4-[[(1E)-(1-cyclohexyl-2,4,6-trioxohexahydropyrimidin-5-yl)methylidene]amino]-1-methylpiperidinium | ZINC05119716 | Trypanosoma cruzi | |
1-[2-(2-chloro-10H-phenothiazin-10-yl)-2-oxoethyl]azepanium | ZINC04866531 | Trypanosoma brucei | |
1-[2-(2-chloro-10H-phenothiazin-10-yl)-2-oxoethyl]azepanium | ZINC04866531 | Trypanosoma cruzi | |
12-chloro-1,1-dimethyl-1,2,3,4,4a,13b-hexahydrodibenzo[2,3:6,7]thiepino[4,5-b]pyridin-1-ium | ZINC00347698 | Trypanosoma brucei | |
12-chloro-1,1-dimethyl-1,2,3,4,4a,13b-hexahydrodibenzo[2,3:6,7]thiepino[4,5-b]pyridin-1-ium | ZINC00347698 | Trypanosoma cruzi | |
2-(2,4-dioxo-1,3-diazaspiro[4.6]undec-3-yl)-N-[2-(phenylsulfanyl)phenyl]acetamide | ZINC03307332 | Trypanosoma brucei | |
2-(2,4-dioxo-1,3-diazaspiro[4.6]undec-3-yl)-N-[2-(phenylsulfanyl)phenyl]acetamide | ZINC03307332 | Trypanosoma cruzi | |
2-(6-methyl-2,4-dioxo-1,3-diazaspiro[4.5]dec-3-yl)-N-[2-(phenylsulfanyl)phenyl]acetamide | ZINC2628155 | Trypanosoma brucei | |
2-(6-methyl-2,4-dioxo-1,3-diazaspiro[4.5]dec-3-yl)-N-[2-(phenylsulfanyl)phenyl]acetamide | ZINC2628155 | Trypanosoma cruzi | |
2-[3-(2-chloro-10H-phenothiazin-10-yl)-3-oxopropyl]octahydro-2H-pyrido[1,2-a]pyrazinediium | ZINC04427277 | Trypanosoma brucei | |
2-[3-(2-chloro-10H-phenothiazin-10-yl)-3-oxopropyl]octahydro-2H-pyrido[1,2-a]pyrazinediium | ZINC04427277 | Trypanosoma cruzi | |
3-((10H-phenothiazin-10-yl)methyl)-1-azoniabicyclo[2.2.2]octane | - |
Trypanosoma brucei | |
3-((10H-phenothiazin-10-yl)methyl)-1-azoniabicyclo[2.2.2]octane | - |
Trypanosoma cruzi | |
3-(11H-dibenzo[b,e][1,4]dithiepin-11-yl)-N,N-dimethylpropan-1-aminium | ZINC00347760 | Trypanosoma brucei | |
3-(11H-dibenzo[b,e][1,4]dithiepin-11-yl)-N,N-dimethylpropan-1-aminium | ZINC00347760 | Trypanosoma cruzi | |
3-(11H-dibenzo[b,e][1,4]oxathiepin-11-ylmethyl)-1-methylpiperidinium | ZINC04128838 | Trypanosoma brucei | |
3-(11H-dibenzo[b,e][1,4]oxathiepin-11-ylmethyl)-1-methylpiperidinium | ZINC04128838 | Trypanosoma cruzi | |
4-[6-[(3-chlorophenyl)carbamoyl]-4-oxo-1,4,5,6-tetrahydropyrimidin-2-yl]-1-methylpiperazin-1-ium | ZINC02240886 | Trypanosoma brucei | |
4-[6-[(3-chlorophenyl)carbamoyl]-4-oxo-1,4,5,6-tetrahydropyrimidin-2-yl]-1-methylpiperazin-1-ium | ZINC02240886 | Trypanosoma cruzi | |
6-(naphthalen-2-ylamino)-6-oxohexane-1,5-diaminium | ZINC01736882 | Trypanosoma brucei | |
6-(naphthalen-2-ylamino)-6-oxohexane-1,5-diaminium | ZINC01736882 | Trypanosoma cruzi | |
N-methyl-N-(2-oxo-2-(2-(phenylthio)phenylamino)ethyl)cyclohexanaminium | - |
Trypanosoma brucei | |
N-methyl-N-(2-oxo-2-(2-(phenylthio)phenylamino)ethyl)cyclohexanaminium | - |
Trypanosoma cruzi | |
N-[2-(phenylsulfanyl)phenyl]-2-[(phenylsulfonyl)amino]propanamide | ZINC00667609 | Trypanosoma brucei | |
N-[2-(phenylsulfanyl)phenyl]-2-[(phenylsulfonyl)amino]propanamide | ZINC00667609 | Trypanosoma cruzi | |
N-[2-[(4-chlorophenyl)sulfanyl]phenyl]-2-(1,3-dioxo-1,3,3a,4,7,7a-hexahydro-2H-isoindol-2-yl)acetamide | ZINC02647011 | Trypanosoma brucei | |
N-[2-[(4-chlorophenyl)sulfanyl]phenyl]-2-(1,3-dioxo-1,3,3a,4,7,7a-hexahydro-2H-isoindol-2-yl)acetamide | ZINC02647011 | Trypanosoma cruzi |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Trypanosoma brucei | P39051 | - |
- |
Trypanosoma cruzi | P28593 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
trypanothione disulfide + NADPH + H+ | - |
Trypanosoma brucei | trypanothione + NADP+ | - |
ir | |
trypanothione disulfide + NADPH + H+ | - |
Trypanosoma cruzi | trypanothione + NADP+ | - |
ir |
Synonyms | Comment | Organism |
---|---|---|
trypanothione reductase | - |
Trypanosoma brucei |
trypanothione reductase | - |
Trypanosoma cruzi |
TryR | - |
Trypanosoma brucei |
TryR | - |
Trypanosoma cruzi |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | - |
Trypanosoma brucei | |
FAD | - |
Trypanosoma cruzi | |
NADPH | - |
Trypanosoma brucei | |
NADPH | - |
Trypanosoma cruzi |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0115 | - |
- |
Trypanosoma cruzi | 3-(11H-dibenzo[b,e][1,4]oxathiepin-11-ylmethyl)-1-methylpiperidinium | |
0.0146 | - |
- |
Trypanosoma brucei | 3-(11H-dibenzo[b,e][1,4]oxathiepin-11-ylmethyl)-1-methylpiperidinium | |
0.0291 | - |
- |
Trypanosoma cruzi | 1-(8-chloro-10,11-dihydrodibenzo[b,f]thiepin-10-yl)-4-ethylpiperazinediium | |
0.0319 | - |
- |
Trypanosoma brucei | 2-[3-(2-chloro-10H-phenothiazin-10-yl)-3-oxopropyl]octahydro-2H-pyrido[1,2-a]pyrazinediium | |
0.0354 | - |
- |
Trypanosoma cruzi | 2-[3-(2-chloro-10H-phenothiazin-10-yl)-3-oxopropyl]octahydro-2H-pyrido[1,2-a]pyrazinediium | |
0.036 | - |
- |
Trypanosoma brucei | 1-(8-chloro-10,11-dihydrodibenzo[b,f]thiepin-10-yl)-4-ethylpiperazinediium | |
0.0367 | - |
- |
Trypanosoma cruzi | 3-(11H-dibenzo[b,e][1,4]dithiepin-11-yl)-N,N-dimethylpropan-1-aminium | |
0.0373 | - |
- |
Trypanosoma brucei | 3-(11H-dibenzo[b,e][1,4]dithiepin-11-yl)-N,N-dimethylpropan-1-aminium | |
0.0452 | - |
- |
Trypanosoma cruzi | 1-benzyl-4-[[(1E)-(1-cyclohexyl-2,4,6-trioxohexahydropyrimidin-5-yl)methylidene]amino]-1-methylpiperidinium | |
0.0587 | - |
- |
Trypanosoma brucei | 12-chloro-1,1-dimethyl-1,2,3,4,4a,13b-hexahydrodibenzo[2,3:6,7]thiepino[4,5-b]pyridin-1-ium | |
0.0753 | - |
- |
Trypanosoma cruzi | 12-chloro-1,1-dimethyl-1,2,3,4,4a,13b-hexahydrodibenzo[2,3:6,7]thiepino[4,5-b]pyridin-1-ium | |
0.0787 | - |
- |
Trypanosoma cruzi | 1-[2-(2-chloro-10H-phenothiazin-10-yl)-2-oxoethyl]azepanium | |
0.0844 | - |
- |
Trypanosoma cruzi | 2-(6-methyl-2,4-dioxo-1,3-diazaspiro[4.5]dec-3-yl)-N-[2-(phenylsulfanyl)phenyl]acetamide | |
0.1 | - |
IC50 above 0.1 mM | Trypanosoma brucei | 1-(2-oxo-2-[[2-(phenylsulfanyl)phenyl]amino]ethyl)-4-phenylpiperazin-1-ium | |
0.1 | - |
IC50 above 0.1 mM | Trypanosoma cruzi | 1-(2-oxo-2-[[2-(phenylsulfanyl)phenyl]amino]ethyl)-4-phenylpiperazin-1-ium | |
0.1 | - |
IC50 above 0.1 mM | Trypanosoma brucei | (3'R,4'R)-3'-carbamoyl-1'-(2-oxo-2-[[2-(phenylsulfanyl)phenyl]amino]ethyl)-1,4'-bipiperidinium | |
0.1 | - |
IC50 above 0.1 mM | Trypanosoma cruzi | (3'R,4'R)-3'-carbamoyl-1'-(2-oxo-2-[[2-(phenylsulfanyl)phenyl]amino]ethyl)-1,4'-bipiperidinium | |
0.1 | - |
IC50 above 0.1 mM | Trypanosoma brucei | 1-[2-(2-chloro-10H-phenothiazin-10-yl)-2-oxoethyl]azepanium | |
0.1 | - |
IC50 above 0.1 mM | Trypanosoma brucei | 1-(3-bromobenzyl)-5,7-dimethyl-1,3-diazoniatricyclo[3.3.1.13,7]decane | |
0.1 | - |
IC50 above 0.1 mM | Trypanosoma cruzi | 1-(3-bromobenzyl)-5,7-dimethyl-1,3-diazoniatricyclo[3.3.1.13,7]decane | |
0.1 | - |
IC50 above 0.1 mM | Trypanosoma brucei | N-[2-[(4-chlorophenyl)sulfanyl]phenyl]-2-(1,3-dioxo-1,3,3a,4,7,7a-hexahydro-2H-isoindol-2-yl)acetamide | |
0.1 | - |
IC50 above 0.1 mM | Trypanosoma cruzi | N-[2-[(4-chlorophenyl)sulfanyl]phenyl]-2-(1,3-dioxo-1,3,3a,4,7,7a-hexahydro-2H-isoindol-2-yl)acetamide | |
0.1 | - |
IC50 above 0.1 mM | Trypanosoma brucei | 2-(2,4-dioxo-1,3-diazaspiro[4.6]undec-3-yl)-N-[2-(phenylsulfanyl)phenyl]acetamide | |
0.1 | - |
IC50 above 0.1 mM | Trypanosoma cruzi | 2-(2,4-dioxo-1,3-diazaspiro[4.6]undec-3-yl)-N-[2-(phenylsulfanyl)phenyl]acetamide | |
0.1 | - |
IC50 above 0.1 mM | Trypanosoma brucei | 6-(naphthalen-2-ylamino)-6-oxohexane-1,5-diaminium | |
0.1 | - |
IC50 above 0.1 mM | Trypanosoma cruzi | 6-(naphthalen-2-ylamino)-6-oxohexane-1,5-diaminium | |
0.1 | - |
IC50 above 0.1 mM | Trypanosoma brucei | 1-(4-methylphenyl)-5-oxo-N-[2-(phenylsulfanyl)phenyl]pyrrolidine-3-carboxamide | |
0.1 | - |
IC50 above 0.1 mM | Trypanosoma cruzi | 1-(4-methylphenyl)-5-oxo-N-[2-(phenylsulfanyl)phenyl]pyrrolidine-3-carboxamide | |
0.1 | - |
IC50 above 0.1 mM | Trypanosoma brucei | 2-(6-methyl-2,4-dioxo-1,3-diazaspiro[4.5]dec-3-yl)-N-[2-(phenylsulfanyl)phenyl]acetamide | |
0.1 | - |
IC50 above 0.1 mM | Trypanosoma brucei | N-[2-(phenylsulfanyl)phenyl]-2-[(phenylsulfonyl)amino]propanamide | |
0.1 | - |
IC50 above 0.1 mM | Trypanosoma cruzi | N-[2-(phenylsulfanyl)phenyl]-2-[(phenylsulfonyl)amino]propanamide | |
0.1 | - |
IC50 above 0.1 mM | Trypanosoma brucei | 1-benzyl-4-[[(1E)-(1-cyclohexyl-2,4,6-trioxohexahydropyrimidin-5-yl)methylidene]amino]-1-methylpiperidinium | |
0.1 | - |
IC50 above 0.1 mM | Trypanosoma brucei | 4-[6-[(3-chlorophenyl)carbamoyl]-4-oxo-1,4,5,6-tetrahydropyrimidin-2-yl]-1-methylpiperazin-1-ium | |
0.1 | - |
IC50 above 0.1 mM | Trypanosoma cruzi | 4-[6-[(3-chlorophenyl)carbamoyl]-4-oxo-1,4,5,6-tetrahydropyrimidin-2-yl]-1-methylpiperazin-1-ium |