Application | Comment | Organism |
---|---|---|
pharmacology | enzyme is a drug target | Entamoeba histolytica |
Cloned (Comment) | Organism |
---|---|
gene EHTR, DNA and amino acid sequence determination and analysis, phylogenetic analysis | Entamoeba histolytica |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
trypanothione disulfide + NADPH | Entamoeba histolytica | - |
trypanothione + NADP+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Entamoeba histolytica | Q8MZR8 | putative, fragment; human parasite, strain HK9 | - |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
trypanothione + NADP+ = trypanothione disulfide + NADPH + H+ | reducing catalytic site CVNVGC | Entamoeba histolytica |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
trophozoite | - |
Entamoeba histolytica | - |
trypanosomoid form | - |
Entamoeba histolytica | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
trypanothione disulfide + NADPH | - |
Entamoeba histolytica | trypanothione + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
TR | - |
Entamoeba histolytica |
trypanothione reductase | - |
Entamoeba histolytica |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
assay at | Entamoeba histolytica |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Entamoeba histolytica |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | 2 molecules per enzyme dimer | Entamoeba histolytica | |
NADPH | dependent on | Entamoeba histolytica |