Application | Comment | Organism |
---|---|---|
medicine | target enzyme for chemotherapy against Chagas' disease | Trypanosoma cruzi |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
bisbenzylisoquinoline alkaloids | e.g. cepharanthine, (-)curine, daphnoline, antioquine, limacine, cycleanine | Trypanosoma cruzi | |
cepharanthine | - |
Trypanosoma cruzi | |
cycleanine | - |
Trypanosoma cruzi |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.05 | - |
trypanothione disulfide | with cepharanthine | Trypanosoma cruzi | |
0.099 | - |
trypanothione disulfide | with cycleanine | Trypanosoma cruzi |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Trypanosoma cruzi | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
trypanothione disulfide + NADPH | - |
Trypanosoma cruzi | trypanothione + NADP+ | - |
? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | - |
Trypanosoma cruzi | |
NADPH | - |
Trypanosoma cruzi |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0076 | - |
cepharanthine | - |
Trypanosoma cruzi | |
0.194 | - |
cycleanine | - |
Trypanosoma cruzi |