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Literature summary for 1.8.1.12 extracted from

  • Shames, S.L.; Kimmel, B.E.; Peoples, O.P.; Agabian, N.; Walsh, C.T.
    Trypanothione reductase of Trypanosoma congolense: gene isolation, primary sequence determination, and comparison to glutathione reductase (1988), Biochemistry, 27, 5014-5019.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information activity is dependent on a redox-active cysteine at the active centre Trypanosoma congolense

Cloned(Commentary)

Cloned (Comment) Organism
DNA sequence analysis Trypanosoma congolense

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
53443
-
2 * 53443, DNA sequence Trypanosoma congolense

Organism

Organism UniProt Comment Textmining
Trypanosoma congolense
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
trypanothione disulfide + NADPH
-
Trypanosoma congolense trypanothione + NADP+
-
r

Subunits

Subunits Comment Organism
dimer 2 * 53443, DNA sequence Trypanosoma congolense

Cofactor

Cofactor Comment Organism Structure
FAD
-
Trypanosoma congolense
NADPH
-
Trypanosoma congolense