Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | activity is dependent on a redox-active cysteine at the active centre | Crithidia fasciculata | |
additional information | activity is dependent on a redox-active cysteine at the active centre | Trypanosoma cruzi |
Application | Comment | Organism |
---|---|---|
medicine | inhibition of the enzyme by naphthoquinone and nitrofuran derivatives abolish the cell penetration by the parasite trypomasstigotes, alternate approach to chemotherapy of trypanosomiasis and leishmaniasis, Chagas' disease | Crithidia fasciculata |
medicine | inhibition of the enzyme by naphthoquinone and nitrofuran derivatives abolish the cell penetration by the parasite trypomasstigotes, alternate approach to chemotherapy of trypanosomiasis and leishmaniasis, Chagas' disease | Trypanosoma cruzi |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
nifurtimox | - |
Trypanosoma cruzi |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
trypanothione disulfide + NADPH | Crithidia fasciculata | - |
trypanothione + NADP+ | - |
? | |
trypanothione disulfide + NADPH | Trypanosoma cruzi | - |
trypanothione + NADP+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Crithidia fasciculata | - |
insect-parasitic trypanosomatid | - |
Trypanosoma cruzi | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | naphthoquinones and nitrofuran derivatives are reduced, inhibition of the enzyme | Crithidia fasciculata | ? | - |
? | |
additional information | naphthoquinones and nitrofuran derivatives are reduced, inhibition of the enzyme | Trypanosoma cruzi | ? | - |
? | |
trypanothione disulfide + NADPH | - |
Crithidia fasciculata | trypanothione + NADP+ | - |
? | |
trypanothione disulfide + NADPH | - |
Crithidia fasciculata | trypanothione + NADP+ | - |
r | |
trypanothione disulfide + NADPH | - |
Trypanosoma cruzi | trypanothione + NADP+ | - |
? | |
trypanothione disulfide + NADPH | - |
Trypanosoma cruzi | trypanothione + NADP+ | - |
r |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
27 | - |
assay at | Crithidia fasciculata |
27 | - |
assay at | Trypanosoma cruzi |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.8 | - |
assay at | Crithidia fasciculata |
7.8 | - |
assay at | Trypanosoma cruzi |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | - |
Crithidia fasciculata | |
FAD | - |
Trypanosoma cruzi | |
NADPH | - |
Crithidia fasciculata | |
NADPH | - |
Trypanosoma cruzi |