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BRENDA support

Literature summary for 1.7.3.3 extracted from

  • Kratzer, J.T.; Lanaspa, M.A.; Murphy, M.N.; Cicerchi, C.; Graves, C.L.; Tipton, P.A.; Ortlund, E.A.; Johnson, R.J.; Gaucher, E.A.
    Evolutionary history and metabolic insights of ancient mammalian uricases (2014), Proc. Natl. Acad. Sci. USA, 111, 3763-3768 .
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Mammalia
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General Information

General Information Comment Organism
physiological function ancestral uricases have steadily decreased in activity since the last common ancestor of mammals gave rise to descendent primate lineages. This progressive decrease is correlated with physiological function and (potential) adaptation. Analysis of the 3D distribution of amino acid replacements as they accumulated during evolutionary history Mammalia