Literature summary for 1.7.3.3 extracted from

Scaraffia, P.Y.; Tan, G.; Isoe, J.; Wysocki, V.H.; Wells, M.A.; Miesfeld, R.L.
Discovery of an alternate metabolic pathway for urea synthesis in adult Aedes aegypti mosquitoes (2008), Proc. Natl. Acad. Sci. USA, 105, 518-523.

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Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	1 h after feeding with ammonium chloride highest expression of urate oxidase in fat body, 6 h after feeding with ammonium chloride highest expression of urate oxidase in malpighian tubules	Aedes aegypti
additional information	in fat body 3fold increased expression towards end of blood meal digestion	Aedes aegypti
additional information	in malpighian tubule expression induced in response to a blood meal, maximum level 24 h after feeding	Aedes aegypti

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	reduced levels of mRNA levels of urate oxidase after knock down of urate oxidase gene expression	Aedes aegypti

Organism

Organism	UniProt	Comment	Textmining
Aedes aegypti	Q17J02	NH-Rockefeller strain	-
Aedes aegypti NH-Rockefeller	Q17J02	NH-Rockefeller strain	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
fat body	-	Aedes aegypti	-
malpighian tubule	-	Aedes aegypti	-

Synonyms

Synonyms	Comment	Organism
AaUO	-	Aedes aegypti
Urate oxidase	-	Aedes aegypti

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Release 2023.1 (January 2023)