Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli | Mycobacterium tuberculosis |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
azide | 5 mM, 95.2% inhibition | Mycobacterium tuberculosis | |
EDTA | 5 mM, 99% inhibition | Mycobacterium tuberculosis | |
additional information | not inhibitory: tungstate and iNOS inhibitor 1400 W | Mycobacterium tuberculosis | |
NADH | 5 mM, 92.3% inhibition | Mycobacterium tuberculosis | |
nitrate | 5 mM, 47.4% inhibition | Mycobacterium tuberculosis |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
17.16 | - |
nitrite | pH 7, 37°C | Mycobacterium tuberculosis |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium tuberculosis | A5U4H6 | cf. EC 3.5.4.4 | - |
Mycobacterium tuberculosis ATCC 25177 | A5U4H6 | cf. EC 3.5.4.4 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
nitrite + reduced electron donor | - |
Mycobacterium tuberculosis | NO + H2O + oxidized electron donor | - |
? | |
nitrite + reduced electron donor | - |
Mycobacterium tuberculosis ATCC 25177 | NO + H2O + oxidized electron donor | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 26000, calculated from sequence and SDS-PAGE | Mycobacterium tuberculosis |
Synonyms | Comment | Organism |
---|---|---|
MRA2164 | - |
Mycobacterium tuberculosis |
NirK | - |
Mycobacterium tuberculosis |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
- |
Mycobacterium tuberculosis |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
100 | - |
nitrite | pH 7, 37°C | Mycobacterium tuberculosis |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | - |
- |
Mycobacterium tuberculosis |
Organism | Comment | Expression |
---|---|---|
Mycobacterium tuberculosis | expression is significantly upregulated after nitrite exposure | up |
General Information | Comment | Organism |
---|---|---|
physiological function | purified recombinant MRA2164 protein shows significant nitrite dependent NO synthesizing activity. The knockdown of the MRA2164 gene expression results in a significantly reduced NO level compared to the wild type bacilli with a simultaneous return of its replicative capability | Mycobacterium tuberculosis |