Literature summary for 1.7.1.7 extracted from

Sarwono, A.E.Y.; Suganuma, K.; Mitsuhashi, S.; Okada, T.; Musinguzi, S.P.; Shigetomi, K.; Inoue, N.; Ubukata, M.
Identification and characterization of guanosine 5'-monophosphate reductase of Trypanosoma congolense as a drug target (2017), Parasitol. Int., 66, 537-544 .

Search for more literature for 1.7.1.7

Application

Application	Comment	Organism
drug development	the enzyme is a target for the design of trypanocidal agents, e.g. based on mycophenolic acid	Trypanosoma congolense

Cloned(Commentary)

Cloned (Comment)	Organism
gene TCIL3000_5_1940, recombinant expression in Escherichia coli	Trypanosoma congolense

Inhibitors

Inhibitors	Comment	Organism	Structure
Mycophenolic acid	MPA	Trypanosoma congolense

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
glycosome	constitutive expression of TcGMPR in glycosomes at all of the parasite's developmental stages	Trypanosoma congolense	20015	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
GMP + NADPH + H+	Trypanosoma congolense	-	IMP + NH3 + NADP+	-	?
GMP + NADPH + H+	Trypanosoma congolense IL3000	-	IMP + NH3 + NADP+	-	?

Organism

Organism	UniProt	Comment	Textmining
Trypanosoma congolense	G0UMT0	-	-
Trypanosoma congolense IL3000	G0UMT0	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
GMP + NADPH + H+	-	Trypanosoma congolense	IMP + NH3 + NADP+	-	?
GMP + NADPH + H+	-	Trypanosoma congolense IL3000	IMP + NH3 + NADP+	-	?

Synonyms

Synonyms	Comment	Organism
GMPR	-	Trypanosoma congolense
guanosine 5'-monophosphate reductase	-	Trypanosoma congolense
TcGMPR	-	Trypanosoma congolense
TCIL3000_5_1940	-	Trypanosoma congolense

Cofactor

Cofactor	Comment	Organism	Structure
NADPH	-	Trypanosoma congolense

General Information

General Information	Comment	Organism
physiological function	enzyme GMPR modulates the concentration of intracellular guanosine in the pathogen	Trypanosoma congolense

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Release 2023.1 (January 2023)