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Literature summary for 1.7.1.7 extracted from

  • Salvatore, D.; Bartha, T.; Larsen, P.R.
    The guanosine monophosphate reductase gene is conserved in rats and its expression increases rapidly in brown adipose tissue during cold exposure (1998), J. Biol. Chem., 273, 31092-31096.
    View publication on PubMed
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Cloned(Commentary)

Cloned (Comment) Organism
cDNA Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
NADPH + guanosine 5'-phosphate Rattus norvegicus enzyme may play a role in brown fat response NADP+ + inosine 5'-phosphate + NH3
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Organism

Organism UniProt Comment Textmining
Rattus norvegicus Q9Z244 mRNA increases 30fold in brown adipose tissue within 6 h of cold exposure
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Source Tissue

Source Tissue Comment Organism Textmining
brown adipose tissue
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 Rattus norvegicus
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cardiac muscle 5fold lower than in unstimulated brown adipose tisssue, no increase during cold-stress Rattus norvegicus
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kidney weak expression in cold-stimulated animals Rattus norvegicus
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additional information not expressed in testis, lung, liver or spleen Rattus norvegicus
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skeletal muscle 5fold lower than in unstimulated brown adipose tisssue, no increase during cold-stress Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NADPH + guanosine 5'-phosphate
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 Rattus norvegicus NADP+ + inosine 5'-phosphate + NH3
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 ?
NADPH + guanosine 5'-phosphate enzyme may play a role in brown fat response Rattus norvegicus NADP+ + inosine 5'-phosphate + NH3
-
 ?