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Literature summary for 1.7.1.7 extracted from
- Guanosine 5'-phosphate reductase and its role in the interconversion of purine nucleotides (1960), J. Biol. Chem., 235, 1474-1478.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| AMP | weak | Escherichia coli |  |
| AMP | weak | Klebsiella aerogenes | |
| AMP | weak | Salmonella enterica subsp. enterica serovar Typhimurium | |
| ATP | - |
Escherichia coli | |
| ATP | - |
Klebsiella aerogenes | |
| ATP | - |
Salmonella enterica subsp. enterica serovar Typhimurium | |
| IMP | - |
Escherichia coli | |
| IMP | - |
Klebsiella aerogenes | |
| IMP | - |
Salmonella enterica subsp. enterica serovar Typhimurium | |
| additional information | not inhibited by KCN | Escherichia coli | |
| additional information | not inhibited by KCN | Klebsiella aerogenes | |
| additional information | not inhibited by KCN | Salmonella enterica subsp. enterica serovar Typhimurium |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.096 | - |
GMP | - |
Salmonella enterica subsp. enterica serovar Typhimurium | |
| 0.096 | - |
GMP | - |
Escherichia coli | |
| 0.096 | - |
GMP | - |
Klebsiella aerogenes | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| additional information | no requirement for monovalent or divalent cations | Salmonella enterica subsp. enterica serovar Typhimurium | |
| additional information | no requirement for monovalent or divalent cations | Escherichia coli | |
| additional information | no requirement for monovalent or divalent cations | Klebsiella aerogenes |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
- |
- |
| Klebsiella aerogenes | - |
- |
- |
| Salmonella enterica subsp. enterica serovar Typhimurium | - |
- |
- |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
72.4 units/mg, 1 unit is defined as the amount of enzyme producing a decrease in absorbancy at 340 nm of 0.1 per min | Salmonella enterica subsp. enterica serovar Typhimurium |
| additional information | - |
72.4 units/mg, 1 unit is defined as the amount of enzyme producing a decrease in absorbancy at 340 nm of 0.1 per min | Escherichia coli |
| additional information | - |
72.4 units/mg, 1 unit is defined as the amount of enzyme producing a decrease in absorbancy at 340 nm of 0.1 per min | Klebsiella aerogenes |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| NADPH + guanosine 5'-phosphate | specific for GMP | Salmonella enterica subsp. enterica serovar Typhimurium | NADP+ + inosine 5'-phosphate + NH3 | - |
ir | |
| NADPH + guanosine 5'-phosphate | specific for GMP | Escherichia coli | NADP+ + inosine 5'-phosphate + NH3 | - |
ir | |
| NADPH + guanosine 5'-phosphate | specific for GMP | Klebsiella aerogenes | NADP+ + inosine 5'-phosphate + NH3 | - |
ir | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | 8.2 | - |
Salmonella enterica subsp. enterica serovar Typhimurium |
| 7.5 | 8.2 | - |
Escherichia coli |
| 7.5 | 8.2 | - |
Klebsiella aerogenes |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADPH | specific for | Salmonella enterica subsp. enterica serovar Typhimurium | |
| NADPH | specific for | Escherichia coli | |
| NADPH | specific for | Klebsiella aerogenes | |
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Release 2023.1 (January 2023)
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