Activating Compound | Comment | Organism | Structure |
---|---|---|---|
2-mercaptoethanol | activation | Homo sapiens | |
dithiothreitol | activation | Homo sapiens | |
thioglycolic acid | activation | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
5,5'-dithiobis(2-nitrobenzoate) | 0.66 mM, 33% inhibition after 30 min | Homo sapiens | |
Ca2+ | 10 mM, 54% inhibition | Homo sapiens | |
Cu2+ | - |
Homo sapiens | |
Fe2+ | 10 mM, more than 90% inhibition | Homo sapiens | |
IMP | - |
Homo sapiens | |
Mg2+ | 10 mM, more than 90% inhibition, 1 mM, 12% inhibition | Homo sapiens | |
Mn2+ | - |
Homo sapiens | |
Ni2+ | - |
Homo sapiens | |
p-hydroxymercuribenzoate | 0.66 mM, 18% inhibition after 30 min | Homo sapiens | |
XMP | - |
Homo sapiens | |
Zn2+ | 10 mM, more than 90% inhibition | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0049 | - |
GMP | - |
Homo sapiens | |
0.0085 | - |
NADPH | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
IMP + NH3 + NADP+ = GMP + NADPH + H+ | first order reaction | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
erythrocyte | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.0052 | - |
- |
Homo sapiens |
Storage Stability | Organism |
---|---|
-70°C, 2 months, less than 20% loss of activity | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
NADPH + guanosine 5'-phosphate | - |
Homo sapiens | NADP+ + inosine 5'-phosphate + NH3 | - |
ir |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
67 | - |
15 min, 40% loss of activity | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
- |
Homo sapiens |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
6 | 9 | pH 6: about 50% of activity at maximum, pH 9: about 70% of activity at maximum | Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0011 | - |
XMP | - |
Homo sapiens |