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Literature summary for 1.7.1.2 extracted from

  • Bhushan, B.; Halasz, A.; Spain, J.; Thiboutot, S.; Ampleman, G.; Hawari, J.
    Biotransformation of hexahydro-1,3,5-trinitro-1,3,5-triazine catalyzed by a NAD(P)H: nitrate oxidoreductase from Aspergillus niger (2002), Environ. Sci. Technol., 36, 3104-3108.
    View publication on PubMed
Search for more literature for 1.7.1.2

Application

Application Comment Organism
environmental protection hexahydro-1,3,5-trinitro-1,3,5-triazine is widely used for military and commercial purposes due to its high explosive properties. Hexahydro-1,3,5-trinitro-1,3,5-triazine and its degradation products are toxic, mutagenic and carcinogenic to humans and other biological systems. The biotransformation of hexahydro-1,3,5-trinitro-1,3,5-triazine by NAD(P)H nitrate reductase from Aspergillus niger under anaerobic conditions Aspergillus niger

Organism

Organism UniProt Comment Textmining
Aspergillus niger
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
hexahydro-1,3,5-trinitro-1,3,5-triazine + NADPH
-
 Aspergillus niger hexahydro-1-nitroso-3,5-dinitro-1,3,5-triazine + NADP+ hexahydro-1-nitroso-3,5-dinitro-1,3,5-triazine is the first reduced product formed by a two-electron reduction mechanism. Subsequent reduction of hexahydro-1-nitroso-3,5-dinitro-1,3,5-triazine followed by rapid ring cleavage gives methylenedinitramine which in turn decomposes in water to N2O, NH4+ and HCHO ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 biotransformation of hexahydro-1,3,5-trinitro-1,3,5-triazine Aspergillus niger

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
 biotransformation of hexahydro-1,3,5-trinitro-1,3,5-triazine Aspergillus niger

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Aspergillus niger