BRENDA - Enzyme Database show
show all sequences of 1.6.99.1

Structural insight into the stereoselective production of PGF2alpha by old yellow enzyme from Trypanosoma cruzi

Okamoto, N.; Yamaguchi, K.; Mizohata, E.; Tokuoka, K.; Uchiyama, N.; Sugiyama, S.; Matsumura, H.; Inaka, K.; Urade, Y.; Inoue, T.; J. Biochem. 150, 563-568 (2011)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
overexpression of the enzyme in Escherichia coli
Trypanosoma cruzi
Crystallization (Commentary)
Crystallization
Organism
purified recombinant enzyme in a ternary complex with inhibitor 12-oxophytodienoate and FMN, X-ray diffraction structure determination and analysis at 2.05 A resolution
Trypanosoma cruzi
Inhibitors
Inhibitors
Commentary
Organism
Structure
(9R,13R)-12-oxophytodienoate
-
Trypanosoma cruzi
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
additional information
Trypanosoma cruzi
old yellow enzyme is an NADPH oxidoreductase capable of reducing a variety of compounds, it catalyzes one- or two-electron reduction
?
-
-
-
NADPH + H+ + acceptor
Trypanosoma cruzi
-
NADP+ + reduced acceptor
-
-
?
NADPH + H+ + prostaglandin H2
Trypanosoma cruzi
via FMN cofactor, stereoselective reaction mechanism
NADP+ + prostaglandin F2alpha
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Trypanosoma cruzi
-
-
-
Reaction
Reaction
Commentary
Organism
NADPH + H+ + acceptor = NADP+ + reduced acceptor
reaction mechanism involving a conserved triad of Glu193-His284-Arg249, overview
Trypanosoma cruzi
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
additional information
old yellow enzyme is an NADPH oxidoreductase capable of reducing a variety of compounds, it catalyzes one- or two-electron reduction
725313
Trypanosoma cruzi
?
-
-
-
-
NADPH + H+ + 4-hydroxybenzaldehyde
-
725313
Trypanosoma cruzi
NADP+ + ?
-
-
-
?
NADPH + H+ + acceptor
-
725313
Trypanosoma cruzi
NADP+ + reduced acceptor
-
-
-
?
NADPH + H+ + prostaglandin H2
via FMN cofactor, stereoselective reaction mechanism
725313
Trypanosoma cruzi
NADP+ + prostaglandin F2alpha
-
-
-
?
Temperature Optimum [C]
Temperature Optimum [C]
Temperature Optimum Maximum [C]
Commentary
Organism
25
-
assay at
Trypanosoma cruzi
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7
-
assay at
Trypanosoma cruzi
Cofactor
Cofactor
Commentary
Organism
Structure
FMN
prosthetic group
Trypanosoma cruzi
Ki Value [mM]
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
0.057
-
(9R,13R)-12-oxophytodienoate
pH 7.0, 25C
Trypanosoma cruzi
Cloned(Commentary) (protein specific)
Commentary
Organism
overexpression of the enzyme in Escherichia coli
Trypanosoma cruzi
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
FMN
prosthetic group
Trypanosoma cruzi
Crystallization (Commentary) (protein specific)
Crystallization
Organism
purified recombinant enzyme in a ternary complex with inhibitor 12-oxophytodienoate and FMN, X-ray diffraction structure determination and analysis at 2.05 A resolution
Trypanosoma cruzi
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
(9R,13R)-12-oxophytodienoate
-
Trypanosoma cruzi
Ki Value [mM] (protein specific)
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
0.057
-
(9R,13R)-12-oxophytodienoate
pH 7.0, 25C
Trypanosoma cruzi
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
additional information
Trypanosoma cruzi
old yellow enzyme is an NADPH oxidoreductase capable of reducing a variety of compounds, it catalyzes one- or two-electron reduction
?
-
-
-
NADPH + H+ + acceptor
Trypanosoma cruzi
-
NADP+ + reduced acceptor
-
-
?
NADPH + H+ + prostaglandin H2
Trypanosoma cruzi
via FMN cofactor, stereoselective reaction mechanism
NADP+ + prostaglandin F2alpha
-
-
?
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
additional information
old yellow enzyme is an NADPH oxidoreductase capable of reducing a variety of compounds, it catalyzes one- or two-electron reduction
725313
Trypanosoma cruzi
?
-
-
-
-
NADPH + H+ + 4-hydroxybenzaldehyde
-
725313
Trypanosoma cruzi
NADP+ + ?
-
-
-
?
NADPH + H+ + acceptor
-
725313
Trypanosoma cruzi
NADP+ + reduced acceptor
-
-
-
?
NADPH + H+ + prostaglandin H2
via FMN cofactor, stereoselective reaction mechanism
725313
Trypanosoma cruzi
NADP+ + prostaglandin F2alpha
-
-
-
?
Temperature Optimum [C] (protein specific)
Temperature Optimum [C]
Temperature Optimum Maximum [C]
Commentary
Organism
25
-
assay at
Trypanosoma cruzi
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7
-
assay at
Trypanosoma cruzi
General Information
General Information
Commentary
Organism
additional information
structure modelling of the enzyme with bound substrate prostaglandin H2
Trypanosoma cruzi
General Information (protein specific)
General Information
Commentary
Organism
additional information
structure modelling of the enzyme with bound substrate prostaglandin H2
Trypanosoma cruzi
Other publictions for EC 1.6.99.1
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
740575
Lonsdale
Reduction of alpha,beta-unsatu ...
Bacillus subtilis 168, Bacillus subtilis
J. Am. Chem. Soc.
137
14733-14742
2015
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724683
Rigon
Effects of sciatic nerve trans ...
Rana catesbeiana
Braz. J. Med. Biol. Res.
46
513-520
2013
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4
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1
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740318
Classen
-
Revisiting the enantioselectiv ...
Zymomonas mobilis, Zymomonas mobilis ATCC 29191
ChemCatChem
5
711-713
2013
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726193
Zou
-
The nitric oxide production an ...
Vicia faba
Plant OMICS
5
115-121
2012
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3
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725313
Okamoto
Structural insight into the st ...
Trypanosoma cruzi
J. Biochem.
150
563-568
2011
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1
1
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1
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3
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1
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1
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1
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1
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1
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721342
Coyle
An old yellow enzyme gene cont ...
Trypanosoma cruzi
Appl. Environ. Microbiol.
76
3898-3903
2010
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1
1
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2
2
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671466
Trotter
Old yellow enzymes protect aga ...
Saccharomyces cerevisiae
Appl. Environ. Microbiol.
72
4885-4892
2006
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671848
Brige
Comparative characterization a ...
Shewanella oneidensis
Biochem. J.
394
335-344
2006
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4
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7
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673464
Torres
NADPH-diaphorase histochemical ...
Mus musculus
Exp. Brain Res.
175
292-304
2006
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671730
Nakagawa
A cytosolic cytochrome b5-like ...
Saccharomyces cerevisiae
Biochem. Biophys. Res. Commun.
338
605-609
2005
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1
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672663
Kim
Increased expression of hypoth ...
Mus musculus
Biosci. Biotechnol. Biochem.
69
1978-1981
2005
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672837
Garbossa
Differential distribution of N ...
Homo sapiens
Brain Res.
1034
1-10
2005
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672861
Dudina
Effect of kainate-induced expe ...
Rattus norvegicus
Bull. Exp. Biol. Med.
139
309-312
2005
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672986
Andronowska
Localization and correlation b ...
Sus scrofa
Cell Tissue Res.
321
243-250
2005
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673008
Racekova
Age-related changes of NADPH-d ...
Rattus norvegicus
Cell. Mol. Neurobiol.
25
1093-1105
2005
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673754
Reekmans
Old yellow enzyme interferes w ...
Saccharomyces cerevisiae
FEMS Yeast Res.
5
711-725
2005
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677241
Pragasam
Detection of endothelial nitri ...
Rattus norvegicus, Rattus norvegicus Wistar
Urol. Res.
33
301-308
2005
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168
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655496
Roda
Nitric oxide synthase-dependen ...
Ceratitis capitata
Eur. J. Histochem.
48
141-150
2004
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1
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6
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656762
Haarer
Old yellow enzyme protects the ...
Saccharomyces cerevisiae
Mol. Biol. Cell
15
4522-4531
2004
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1
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1
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657275
Fitzpatrick
Structural and functional impa ...
Bacillus subtilis
Protein Expr. Purif.
36
280-291
2004
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9
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7
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1
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1
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5
2
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11
-
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1
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1
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9
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7
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1
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5
2
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11
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656130
Fitzpatrick
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654136
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The specificity of the histoch ...
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392791
Kerschbaum
NADPH-diaphorase activity and ...
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405-411
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392799
Fox
The flavin environment in old ...
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The oxidative half-reaction of ...
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Nakamura
NADPH-diaphorase and cytosolic ...
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Peng
Induction of NADPH-diaphorase ...
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Brain Res. Bull.
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119-128
1997
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Stengl
NADPH diaphorase activity in t ...
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392790
De-Faria
Biochemical characterization o ...
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1995
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392798
Rabinowitz
NADPH-diaphorase activity in p ...
Sus scrofa
Cell. Mol. Biol. Res.
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1995
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Spessert
Fixation conditions affect the ...
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392803
Fox
Old yellow enzyme at 2 ANG res ...
Saccharomyces pastorianus
Structure
2
1089-1105
1994
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Schmidt
Characterization of NADPH diap ...
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343-348
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392783
Saito
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392784
Fox
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Crystallization and characteri ...
Saccharomyces pastorianus
Flavins and Flavoproteins (Proc. Int. Symp. , 10th, Meeting Date 1990, Curti, B. , Ronchi S. , Zanetti, G. , eds. ) de Gruyter, Berlin, New York
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Miura
On the structure of old yellow ...
Saccharomyces pastorianus
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1311-1320
1987
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392789
Kemp
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Kinetics of rat brain NADPH-di ...
Rattus norvegicus
Biochem. Soc. Trans.
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501
1987
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Massey
Reactivity of old yellow enzym ...
Saccharomyces pastorianus
J. Biol. Chem.
261
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392786
Honma
Kinetic studies of the old yel ...
Saccharomyces pastorianus
Biochim. Biophys. Acta
484
9-23
1977
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