Literature summary for 1.6.5.2 extracted from

Zhang, Y.; den Braver-Sewradj, S.P.; Vos, J.C.; Vermeulen, N.P.E.; Commandeur, J.N.M.
Human glutathione S-transferases- and NAD(P)H quinone oxidoreductase 1-catalyzed inactivation of reactive quinoneimines of amodiaquine and N-desethylamodiaquine Possible implications for susceptibility to amodiaquine-induced liver toxicity (2017), Toxicol. Lett., 275, 83-91 .

Search for more literature for 1.6.5.2

Application

Application	Comment	Organism
medicine	low hepatic expression of the active glutathione S-transferases and NQO1 may increase the susceptibility of patients to amodiaquine idiosyncratic hepatotoxicity. NQO1 inactivates protein reactive quinonimines such as amodiaquine by reduction	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P15559	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Homo sapiens	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
280	-	pH not specified in the publication, temperature not specified in the publication	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
amodiaquine + NAD+	-	Homo sapiens	amodiaquine quinoneimine + NADH + H+	-	r
amodiaquine quinoneimine + NADH + H+	-	Homo sapiens	amodiaquine + NAD+	-	r
N-desethylamodiaquine + NAD+	-	Homo sapiens	N-desethylamodiaquine quinoneimine + NADH + H+	-	r
N-desethylamodiaquine quinoneimine + NADH + H+	-	Homo sapiens	N-desethylamodiaquine + NAD+	-	r
oxidized dichlorophenolindophenol + NADH + H+	-	Homo sapiens	reduced dichlorophenolindophenol + NAD+	-	?

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Release 2023.1 (January 2023)