Literature summary for 1.6.5.2 extracted from

Glorieux, C.; Sandoval, J.M.; Dejeans, N.; Ameye, G.; Poirel, H.A.; Verrax, J.; Calderon, P.B.
Overexpression of NAD(P)H quinone oxidoreductase 1 (NQO1) and genomic gain of the NQO1 locus modulates breast cancer cell sensitivity to quinones (2016), Life Sci., 145, 57-65 .

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Application

Application	Comment	Organism
medicine	NQO1 overexpression is a main determinant for a potential chemotherapy resistance or an increased sensitivity to quinone-bearing compounds	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P15559	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
250MK cell	-	Homo sapiens	-
MCF-7 cell	oxidative stress-resistant MCF-7 breast cancer cells, derived from MCF-7 cells, which were rendered resistant by chronic exposure to an H2O2-generating system made by mixing a redox cycler (menadione) with a reducing agent such as ascorbate.	Homo sapiens	-

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Release 2023.1 (January 2023)