Literature summary for 1.6.5.2 extracted from

Jackson, S.J.; Singletary, K.W.; Murphy, L.L.; Venema, R.C.; Young, A.J.
Phytonutrients differentially stimulate NAD(P)H quinone oxidoreductase, inhibit proliferation, and trigger mitotic catastrophe in Hepa1c1c7 cells (2016), J. Med. Food, 19, 47-53 .

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Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q64669	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
Hepa-1c1c7 cell	-	Mus musculus	-

Expression

Organism	Comment	Expression
Mus musculus	sulforaphane or curcumin significantly increase NQO1 protein expression and activity without triggering G2/M cell cycle arrest or mitotic catastrophe. Sulforaphane and curcumin each increase the NQO1 activity within 24 h, at concentrations as low as 0.1 microM. The minimal quercetin concentration inducing NQO1, is 100fold higher than that which disrupts mitosis. Resveratrol modestly stimulates NQO1, but the minimally effective resveratrol concentration concomitantly induces evidence of cellular apoptosis	up

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Release 2023.1 (January 2023)