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Literature summary for 1.6.5.2 extracted from

  • Kummarapurugu, A.B.; Fischer, B.M.; Zheng, S.; Milne, G.L.; Ghio, A.J.; Potts-Kant, E.N.; Foster, W.M.; Soderblom, E.J.; Dubois, L.G.; Moseley, M.A.; Thompson, J.W.; Voynow, J.A.
    NADPH quinone oxidoreductase 1 regulates host susceptibility to ozone via isoprostane generation (2013), J. Biol. Chem., 288, 4681-4691 .
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Mus musculus Q64669
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General Information

General Information Comment Organism
physiological function NQO1-null mice have greater lung tissue levels of D2- and E2-isoprostanes, the precursors of J2- and A2-isoprostanes, both at base line and following ozone exposure. A2-isoprostane inhibits ozone-induced NF-kappaB activation and IL-8 regulation Mus musculus