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Literature summary for 1.6.5.2 extracted from

  • Zhang, W.; Go, M.L.
    Methoxylation of resveratrol: effects on induction of NAD(P)H quinone-oxidoreductase 1 (NQO1) activity and growth inhibitory properties (2011), Bioorg. Med. Chem. Lett., 21, 1032-1035.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
2,2'-dimethoxy-trans-stilbene
-
Homo sapiens
2,2'-dimethoxy-trans-stilbene
-
Mus musculus
2,4'-dimethoxy-cis-stilbene
-
Homo sapiens
2,4'-dimethoxy-cis-stilbene
-
Mus musculus
2,4'-dimethoxy-trans-stilbene
-
Homo sapiens
2,4'-dimethoxy-trans-stilbene
-
Mus musculus
2,4,4'-trimethoxy-cis-stilbene
-
Homo sapiens
2,4,4'-trimethoxy-cis-stilbene
-
Mus musculus
2,4,4'-trimethoxy-trans-stilbene
-
Homo sapiens
2,4,4'-trimethoxy-trans-stilbene
-
Mus musculus
2,6,4'-trimethoxy-trans-stilbene
-
Homo sapiens
2,6,4'-trimethoxy-trans-stilbene
-
Mus musculus
2-hydroxy-4'-methoxy-trans-stilbene
-
Homo sapiens
2-hydroxy-4'-methoxy-trans-stilbene
-
Mus musculus
3,4'-dimethoxy-cis-stilbene
-
Homo sapiens
3,4'-dimethoxy-cis-stilbene
-
Mus musculus
3,4'-dimethoxy-trans-stilbene
-
Mus musculus
3,4,4'-trimethoxy-cis-stilbene
-
Homo sapiens
3,4,4'-trimethoxy-cis-stilbene
-
Mus musculus
3,4,4'-trimethoxy-trans-stilbene
-
Homo sapiens
3,4,4'-trimethoxy-trans-stilbene
-
Mus musculus
3,4,5,4'-tetramethoxy-cis-stilbene
-
Homo sapiens
3,4,5,4'-tetramethoxy-cis-stilbene
-
Mus musculus
3,4,5,4'-tetramethoxy-trans-stilbene
-
Homo sapiens
3,4,5,4'-tetramethoxy-trans-stilbene
-
Mus musculus
3,5,4'-trimethoxy-cis-stilbene
-
Homo sapiens
3,5,4'-trimethoxy-cis-stilbene
-
Mus musculus
3,5,4'-trimethoxy-trans-stilbene
-
Homo sapiens
3,5,4'-trimethoxy-trans-stilbene
-
Mus musculus
3,5-dihydroxy-4'-methoxy-cis-stilbene
-
Homo sapiens
3,5-dihydroxy-4'-methoxy-cis-stilbene
-
Mus musculus
3,5-dihydroxy-4'-methoxy-trans-stilbene
-
Homo sapiens
3,5-dihydroxy-4'-methoxy-trans-stilbene
-
Mus musculus
3-hydroxy-4'-methoxy-cis-stilbene
-
Homo sapiens
3-hydroxy-4'-methoxy-cis-stilbene
-
Mus musculus
3-hydroxy-4'-methoxy-trans-stilbene
-
Homo sapiens
3-hydroxy-4'-methoxy-trans-stilbene
-
Mus musculus
3-hydroxy-4,4'-dimethoxy-cis-stilbene
-
Homo sapiens
3-hydroxy-4,4'-dimethoxy-cis-stilbene
-
Mus musculus
3-hydroxy-4,4'-dimethoxy-trans-stilbene
-
Homo sapiens
3-hydroxy-4,4'-dimethoxy-trans-stilbene
-
Mus musculus
4,4'-dimethoxy-cis-stilbene
-
Homo sapiens
4,4'-dimethoxy-cis-stilbene
-
Mus musculus
4,4'-dimethoxy-trans-stilbene
-
Homo sapiens
4,4'-dimethoxy-trans-stilbene
-
Mus musculus
cis-stilbene
-
Homo sapiens
additional information growth inhibitory effects of series of methoxystilbenes (E and Z isomers) related to resveratrol on human cancer cell lines, overview Homo sapiens
additional information enzyme induction effects of series of methoxystilbenes (E and Z isomers) related to resveratrol on murine hepatoma cells, overview Mus musculus
pinosylvin
-
Homo sapiens
resveratrol
-
Homo sapiens
resveratrol
-
Mus musculus
trans-stilbene
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HCT-116 cell
-
Homo sapiens
-
Hepa-1c1c7 cell
-
Mus musculus
-
IMR-90 cell
-
Homo sapiens
-
MCF-7 cell
-
Homo sapiens
-

Synonyms

Synonyms Comment Organism
NAD(P)H quinone-oxidoreductase 1
-
Mus musculus
NAD(P)H quinone-oxidoreductase 1
-
Homo sapiens
NQO1
-
Mus musculus
NQO1
-
Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000015
-
pH not specified in the publication, 37°C, MCF-7 cells Homo sapiens 3,4,5,4'-tetramethoxy-cis-stilbene
0.00002
-
pH not specified in the publication, 37°C, HCT-116 cells Homo sapiens 3,4,5,4'-tetramethoxy-cis-stilbene
0.00002
-
pH not specified in the publication, 37°C, IMR-90 cells Homo sapiens 3,4,5,4'-tetramethoxy-cis-stilbene
0.000034
-
pH not specified in the publication, 37°C Mus musculus 3,4,5,4'-tetramethoxy-cis-stilbene
0.00012
-
pH not specified in the publication, 37°C, MCF-7 cells Homo sapiens 3,5,4'-trimethoxy-cis-stilbene
0.00016
-
pH not specified in the publication, 37°C, IMR-90 cells Homo sapiens 3,4,5,4'-tetramethoxy-trans-stilbene
0.00022
-
pH not specified in the publication, 37°C, HCT-116 cells Homo sapiens 3,5,4'-trimethoxy-cis-stilbene
0.00022
-
pH not specified in the publication, 37°C, MCF-7 cells Homo sapiens 3,4,5,4'-tetramethoxy-trans-stilbene
0.00023
-
pH not specified in the publication, 37°C, IMR-90 cells Homo sapiens 3,5,4'-trimethoxy-cis-stilbene
0.00053
-
pH not specified in the publication, 37°C, HCT-116 cells Homo sapiens 3,4,5,4'-tetramethoxy-trans-stilbene
0.00059
-
pH not specified in the publication, 37°C Mus musculus 3,5,4'-trimethoxy-cis-stilbene
0.001
-
pH not specified in the publication, 37°C Mus musculus 3,4,5,4'-tetramethoxy-trans-stilbene
0.0011
-
pH not specified in the publication, 37°C, MCF-7 cells Homo sapiens 3,5,4'-trimethoxy-trans-stilbene
0.0021
-
pH not specified in the publication, 37°C, IMR-90 cells Homo sapiens 3,5,4'-trimethoxy-trans-stilbene
0.0023
-
pH not specified in the publication, 37°C, HCT-116 cells Homo sapiens 2,4,4'-trimethoxy-cis-stilbene
0.0023
-
pH not specified in the publication, 37°C, HCT-116 cells Homo sapiens 3,4,4'-trimethoxy-cis-stilbene
0.0024
-
pH not specified in the publication, 37°C, MCF-7 cells Homo sapiens 3,4,4'-trimethoxy-cis-stilbene
0.0025
-
pH not specified in the publication, 37°C, MCF-7 cells Homo sapiens 2,4,4'-trimethoxy-cis-stilbene
0.0034
-
pH not specified in the publication, 37°C, HCT-116 cells Homo sapiens 3-hydroxy-4,4'-dimethoxy-cis-stilbene
0.0042
-
pH not specified in the publication, 37°C, MCF-7 cells Homo sapiens 3-hydroxy-4,4'-dimethoxy-cis-stilbene
0.0044
-
pH not specified in the publication, 37°C, MCF-7 cells Homo sapiens 3,4'-dimethoxy-cis-stilbene
0.0051
-
pH not specified in the publication, 37°C Mus musculus 3,4,4'-trimethoxy-cis-stilbene
0.0051
-
pH not specified in the publication, 37°C, HCT-116 cells Homo sapiens 3,4'-dimethoxy-cis-stilbene
0.0051
-
pH not specified in the publication, 37°C, MCF-7 cells Homo sapiens 2,4'-dimethoxy-cis-stilbene
0.0052
-
pH not specified in the publication, 37°C Mus musculus 3,5,4'-trimethoxy-trans-stilbene
0.0056
-
pH not specified in the publication, 37°C, IMR-90 cells Homo sapiens 2,4,4'-trimethoxy-cis-stilbene
0.0057
-
pH not specified in the publication, 37°C, HCT-116 cells Homo sapiens 3,5,4'-trimethoxy-trans-stilbene
0.0059
-
pH not specified in the publication, 37°C, HCT-116 cells Homo sapiens 2,4'-dimethoxy-cis-stilbene
0.006
-
pH not specified in the publication, 37°C, IMR-90 cells Homo sapiens 3-hydroxy-4,4'-dimethoxy-cis-stilbene
0.007
-
pH not specified in the publication, 37°C, IMR-90 cells Homo sapiens 3,4,4'-trimethoxy-cis-stilbene
0.0081
-
pH not specified in the publication, 37°C Mus musculus 2,4,4'-trimethoxy-cis-stilbene
0.0095
-
pH not specified in the publication, 37°C, IMR-90 cells Homo sapiens 3,4'-dimethoxy-cis-stilbene
0.0097
-
pH not specified in the publication, 37°C Mus musculus 3,4'-dimethoxy-cis-stilbene
0.0103
-
pH not specified in the publication, 37°C Mus musculus 2,6,4'-trimethoxy-trans-stilbene
0.0104
-
pH not specified in the publication, 37°C, IMR-90 cells Homo sapiens 2,4'-dimethoxy-cis-stilbene
0.0115
-
pH not specified in the publication, 37°C Mus musculus 2,4'-dimethoxy-cis-stilbene
0.025
-
above, pH not specified in the publication, 37°C Mus musculus 3-hydroxy-4,4'-dimethoxy-cis-stilbene
0.025
-
above, pH not specified in the publication, 37°C Mus musculus 2,4'-dimethoxy-trans-stilbene
0.025
-
above, pH not specified in the publication, 37°C Mus musculus 4,4'-dimethoxy-trans-stilbene
0.025
-
above, pH not specified in the publication, 37°C Mus musculus 4,4'-dimethoxy-cis-stilbene
0.025
-
above, pH not specified in the publication, 37°C Mus musculus 2,4,4'-trimethoxy-trans-stilbene
0.025
-
above, pH not specified in the publication, 37°C Mus musculus 3,4,4'-trimethoxy-trans-stilbene
0.025
-
above, pH not specified in the publication, 37°C Mus musculus 2-hydroxy-4'-methoxy-trans-stilbene
0.025
-
above, pH not specified in the publication, 37°C Mus musculus 3-hydroxy-4'-methoxy-trans-stilbene
0.025
-
above, pH not specified in the publication, 37°C Mus musculus 3-hydroxy-4'-methoxy-cis-stilbene
0.025
-
above, pH not specified in the publication, 37°C Mus musculus 3,5-dihydroxy-4'-methoxy-trans-stilbene
0.025
-
above, pH not specified in the publication, 37°C Mus musculus 3,5-dihydroxy-4'-methoxy-cis-stilbene
0.025
-
above, pH not specified in the publication, 37°C Mus musculus 3-hydroxy-4,4'-dimethoxy-trans-stilbene
0.025
-
above, pH not specified in the publication, 37°C Mus musculus 2,2'-dimethoxy-trans-stilbene
0.025
-
above, pH not specified in the publication, 37°C Mus musculus 3,4'-dimethoxy-trans-stilbene