Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | is elevated in many tumors | Mus musculus | |
additional information | is elevated in many tumors | Homo sapiens | |
additional information | is elevated in many tumors | Rattus norvegicus |
Application | Comment | Organism |
---|---|---|
medicine | main function of QR1 is probably the detoxification of dietary quinones but it may also contribute to the reduction of vitamin K for its involvement in blood coagluation | Mus musculus |
medicine | main function of QR1 is probably the detoxification of dietary quinones but it may also contribute to the reduction of vitamin K for its involvement in blood coagluation | Homo sapiens |
medicine | main function of QR1 is probably the detoxification of dietary quinones but it may also contribute to the reduction of vitamin K for its involvement in blood coagluation | Rattus norvegicus |
medicine | plays a protective role against the induction of renal tumors by diethylstilbestrol | Mesocricetus auratus |
Crystallization (Comment) | Organism |
---|---|
apo QR1 and QR1 in complex with duroquinone, to 2.0 A resolution | Homo sapiens |
QR1 in complex with NADP+ or QR1 in complex with duroquinone | Rattus norvegicus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | QR1-deficient individuals exposed to occupational benzene are at a substantially higher risk of contracting leukemia than normal individuals | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
dicoumarol | - |
Homo sapiens | |
dicoumarol | - |
Mus musculus | |
dicoumarol | - |
Rattus norvegicus | |
ES936 | is an irreversible mechanism-based inhibitor of QR1 | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Mus musculus | 5829 | - |
cytosol | - |
Homo sapiens | 5829 | - |
cytosol | - |
Rattus norvegicus | 5829 | - |
cytosol | - |
Mesocricetus auratus | 5829 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mesocricetus auratus | - |
- |
- |
Mus musculus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Subunits | Comment | Organism |
---|---|---|
dimer | - |
Mus musculus |
dimer | - |
Homo sapiens |
homodimer | - |
Rattus norvegicus |
Synonyms | Comment | Organism |
---|---|---|
DT-diaphorase | - |
Mus musculus |
DT-diaphorase | - |
Homo sapiens |
DT-diaphorase | - |
Rattus norvegicus |
DT-diaphorase | - |
Mesocricetus auratus |
EC 1.6.99.2 | formerly | Mus musculus |
EC 1.6.99.2 | formerly | Homo sapiens |
EC 1.6.99.2 | formerly | Rattus norvegicus |
EC 1.6.99.2 | formerly | Mesocricetus auratus |
NAD(P)H:quinone acceptor oxidoreductase | - |
Mus musculus |
NAD(P)H:quinone acceptor oxidoreductase | - |
Homo sapiens |
NAD(P)H:quinone acceptor oxidoreductase | - |
Rattus norvegicus |
NAD(P)H:quinone acceptor oxidoreductase | - |
Mesocricetus auratus |
NQO1 | - |
Mus musculus |
NQO1 | - |
Homo sapiens |
NQO1 | - |
Rattus norvegicus |
NQO1 | - |
Mesocricetus auratus |
QR1 | - |
Mus musculus |
QR1 | - |
Homo sapiens |
QR1 | - |
Rattus norvegicus |
QR1 | - |
Mesocricetus auratus |
quinone reductase type 1 | - |
Mus musculus |
quinone reductase type 1 | - |
Homo sapiens |
quinone reductase type 1 | - |
Rattus norvegicus |
quinone reductase type 1 | - |
Mesocricetus auratus |
Vitamin K reductase | - |
Mus musculus |
Vitamin K reductase | - |
Homo sapiens |
Vitamin K reductase | - |
Rattus norvegicus |
Vitamin K reductase | - |
Mesocricetus auratus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | - |
Mus musculus | |
FAD | - |
Homo sapiens | |
FAD | - |
Rattus norvegicus | |
NADH | - |
Mus musculus | |
NADH | - |
Homo sapiens | |
NADH | - |
Rattus norvegicus | |
NADPH | - |
Mus musculus | |
NADPH | - |
Homo sapiens | |
NADPH | - |
Rattus norvegicus |