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Literature summary for 1.6.5.2 extracted from

  • Bianchet, M.A.; Erdemli, S.B.; Amzel, L.M.
    Structure, function, and mechanism of cytosolic quinone reductases (2008), Vitam. Horm., 78, 63-84.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information is elevated in many tumors Mus musculus
additional information is elevated in many tumors Homo sapiens
additional information is elevated in many tumors Rattus norvegicus

Application

Application Comment Organism
medicine main function of QR1 is probably the detoxification of dietary quinones but it may also contribute to the reduction of vitamin K for its involvement in blood coagluation Mus musculus
medicine main function of QR1 is probably the detoxification of dietary quinones but it may also contribute to the reduction of vitamin K for its involvement in blood coagluation Homo sapiens
medicine main function of QR1 is probably the detoxification of dietary quinones but it may also contribute to the reduction of vitamin K for its involvement in blood coagluation Rattus norvegicus
medicine plays a protective role against the induction of renal tumors by diethylstilbestrol Mesocricetus auratus

Crystallization (Commentary)

Crystallization (Comment) Organism
apo QR1 and QR1 in complex with duroquinone, to 2.0 A resolution Homo sapiens
QR1 in complex with NADP+ or QR1 in complex with duroquinone Rattus norvegicus

Protein Variants

Protein Variants Comment Organism
additional information QR1-deficient individuals exposed to occupational benzene are at a substantially higher risk of contracting leukemia than normal individuals Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
dicoumarol
-
Homo sapiens
dicoumarol
-
Mus musculus
dicoumarol
-
Rattus norvegicus
ES936 is an irreversible mechanism-based inhibitor of QR1 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Mus musculus 5829
-
cytosol
-
Homo sapiens 5829
-
cytosol
-
Rattus norvegicus 5829
-
cytosol
-
Mesocricetus auratus 5829
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mesocricetus auratus
-
-
-
Mus musculus
-
-
-
Rattus norvegicus
-
-
-

Subunits

Subunits Comment Organism
dimer
-
Mus musculus
dimer
-
Homo sapiens
homodimer
-
Rattus norvegicus

Synonyms

Synonyms Comment Organism
DT-diaphorase
-
Mus musculus
DT-diaphorase
-
Homo sapiens
DT-diaphorase
-
Rattus norvegicus
DT-diaphorase
-
Mesocricetus auratus
EC 1.6.99.2 formerly Mus musculus
EC 1.6.99.2 formerly Homo sapiens
EC 1.6.99.2 formerly Rattus norvegicus
EC 1.6.99.2 formerly Mesocricetus auratus
NAD(P)H:quinone acceptor oxidoreductase
-
Mus musculus
NAD(P)H:quinone acceptor oxidoreductase
-
Homo sapiens
NAD(P)H:quinone acceptor oxidoreductase
-
Rattus norvegicus
NAD(P)H:quinone acceptor oxidoreductase
-
Mesocricetus auratus
NQO1
-
Mus musculus
NQO1
-
Homo sapiens
NQO1
-
Rattus norvegicus
NQO1
-
Mesocricetus auratus
QR1
-
Mus musculus
QR1
-
Homo sapiens
QR1
-
Rattus norvegicus
QR1
-
Mesocricetus auratus
quinone reductase type 1
-
Mus musculus
quinone reductase type 1
-
Homo sapiens
quinone reductase type 1
-
Rattus norvegicus
quinone reductase type 1
-
Mesocricetus auratus
Vitamin K reductase
-
Mus musculus
Vitamin K reductase
-
Homo sapiens
Vitamin K reductase
-
Rattus norvegicus
Vitamin K reductase
-
Mesocricetus auratus

Cofactor

Cofactor Comment Organism Structure
FAD
-
Mus musculus
FAD
-
Homo sapiens
FAD
-
Rattus norvegicus
NADH
-
Mus musculus
NADH
-
Homo sapiens
NADH
-
Rattus norvegicus
NADPH
-
Mus musculus
NADPH
-
Homo sapiens
NADPH
-
Rattus norvegicus