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Literature summary for 1.6.5.2 extracted from

  • Song, C.W.; Chae, J.J.; Choi, E.K.; Hwang, T.S.; Kim, C.; Lim, B.U.; Park, H.J.
    Anti-cancer effect of bio-reductive drug beta-lapachon is enhanced by activating NQO1 with heat shock (2008), Int. J. Hyperthermia, 24, 161-169.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information heating at 42°C for 1 h significantly increases the expression of NQO1 in cancer cells Mus musculus
additional information heating at 42°C for 1 h significantly increases the expression of NQO1 in cancer cells Homo sapiens

Application

Application Comment Organism
drug development mild temperature heat shock elevates the NQO1 expression in cancer cells, which in turn markedly increases the sensitivity of the cells to the bioreductive drug beta-lapachone in vitro and in vivo Mus musculus
drug development mild temperature heat shock elevates the NQO1 expression in cancer cells, which in turn markedly increases the sensitivity of the cells to the bioreductive drug beta-lapachone in vitro and in vivo Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
C3H mice
-
Mus musculus C3H
-
C3H mice
-

Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell
-
Homo sapiens
-
fibrosarcoma cell
-
Mus musculus
-
lung cancer cell
-
Homo sapiens
-

Synonyms

Synonyms Comment Organism
NAD(P)H: Quinone oxidoreductase
-
Mus musculus
NAD(P)H: Quinone oxidoreductase
-
Homo sapiens
NQO1
-
Mus musculus
NQO1
-
Homo sapiens