Literature summary for 1.6.5.2 extracted from

Tsvetkov, P.; Asher, G.; Reiss, V.; Shaul, Y.; Sachs, L.; Lotem, J.
Inhibition of NAD(P)H:quinone oxidoreductase 1 activity and induction of p53 degradation by the natural phenolic compound curcumin (2005), Proc. Natl. Acad. Sci. USA, 102, 5535-5540.

Inhibitors

Inhibitors	Comment	Organism	Structure
curcumin	inhibition of enzyme activity in vivo and in vitro. Inducues dissociation of complexes of enzyme with tumor suppressor protein p53 leading to degradation of p53, but not of p53 cancer hot-spot mutant R273H	Mus musculus

Organism	UniProt	Comment	Textmining
Mus musculus	-	recombinant and native enzyme	-

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Release 2023.1 (January 2023)