Literature summary for 1.6.5.2 extracted from

Foppoli, C.; De Marco, F.; Blarzino, C.; Perluigi, M.; Cini, C.; Coccia, R.
Biological response of human diploid keratinocytes to quinone-producing compounds: role of NAD(P)H:quinone oxidoreductase 1 (2005), Int. J. Biochem. Cell Biol., 37, 852-863.

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Activating Compound

Activating Compound	Comment	Organism	Structure
1-(3,4-dihydroxybenzyl)-1,2,3,4-tetrahydro-6,7-isoquinolinediol	up-regulation of enzyme upon exposure to L-dopa and tetrahydropapaveroline	Homo sapiens
L-Dopa	up-regulation of enzyme upon exposure to L-dopa and tetrahydropapaveroline	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Homo sapiens	enzyme contributes to the capacity of keratinocytes to protect epidermis against oxidant stress	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P15559	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
keratinocyte	up-regulation of enzyme upon exposure to L-dopa and tetrahydropapaveroline	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	enzyme contributes to the capacity of keratinocytes to protect epidermis against oxidant stress	Homo sapiens	?	-	?

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Release 2023.1 (January 2023)