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Literature summary for 1.6.5.2 extracted from

  • Nemeikaite-Ceniene, A.; Dringeliene, A.; Sarlauskas, J.; Cenas, N.
    Role of NAD(P)H:quinone oxidoreductase (NQO1) in apoptosis induction by aziridinylbenzoquinones RH1 and MeDZQ (2005), Acta Biochim. Pol., 52, 937-941.
    View publication on PubMed
Search for more literature for 1.6.5.2

Application

Application Comment Organism
medicine antitumour quinones 2,5-diaziridinyl-3-hydroxymethyl-6-methyl-1,4-benzoquinone and 2,5-dimethyl-3,6-diaziridinyl-1,4-benzoquinone, i.e. RH1 and MeDZQ resp., induce apoptosis via enzyme-linked formation of alkylating species rather than via enzyme-linked redox cycling Ovis aries

Organism

Organism UniProt Comment Textmining
Ovis aries
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Source Tissue

Source Tissue Comment Organism Textmining
FLK cell bovine leukemia virus-transformed lamb kidney fibroblast cell line Ovis aries
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NAD(P)H + H+ + 2,5-diaziridinyl-3-hydroxymethyl-6-methyl-1,4-benzoquinone i.e. RH1, induction of apoptosis via enzyme-linked formation of alkylating species Ovis aries NAD(P)+ + reduced 2,5-diaziridinyl-3-hydroxymethyl-6-methyl-1,4-benzoquinone
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 ?
NAD(P)H + H+ + 2,5-dimethyl-3,6-diaziridinyl-1,4-benzoquinone i.e. MeDZQ, induction of apoptosis via enzyme-linked formation of alkylating species Ovis aries NAD(P)+ + reduced 2,5-dimethyl-3,6-diaziridinyl-1,4-benzoquinone
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 ?