Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | NQO1 activity colocalizes closely with Alzheimers disease pathology supporting a presumed role as an antioxidant system upregulated in response to the oxidative stress of the Alzheimers disease process | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | the ratio of frontal to cerebellar NQO1 activity is significantly increased in patients with Alzheimers disease versus controls, specific localization to astrocytes and neurites surrounding senile plaques. Neuronal NQO1 staining seen in frontal cortex of Alzheimers disease patients is absent in frontal cortex of controls, but is found to the same extent in neurons of the substantia nigra of both Alzheimers disease patients and controls | Homo sapiens | - |
cerebellar cortex | the ratio of frontal to cerebellar NQO1 activity is significantly increased in patients with Alzheimers disease versus controls | Homo sapiens | - |
cerebellum | the ratio of frontal to cerebellar NQO1 activity is significantly increased in patients with Alzheimers disease versus controls | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | NQO1 activity colocalizes closely with Alzheimers disease pathology supporting a presumed role as an antioxidant system upregulated in response to the oxidative stress of the Alzheimers disease process | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
NAD(P)H:quinone oxidoreductase | - |
Homo sapiens |
NQO1 | - |
Homo sapiens |