Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.6.5.2 extracted from

  • Anusevicius, Z.; Sarlauskas, J.; Cenas, N.
    Two-electron reduction of quinones by rat liver NAD(P)H:quinone oxidoreductase: quantitative structure-activity relationships (2002), Arch. Biochem. Biophys., 404, 254-262.
    View publication on PubMed
Search for more literature for 1.6.5.2

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus plays one of the main roles in the bioactivation of quinoidal drugs ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1,4-benzoquinone + NADPH
-
 Rattus norvegicus 1,4-benzosemiquinone + NADP+
-
 ?
1,4-naphthoquinone + NADPH + H+
-
 Rattus norvegicus 1,4-naphthoquinol + NADP+
-
 ?
1,8-dihydroxy-9,10-anthraquinone + NADPH
-
 Rattus norvegicus 1,8-dihydroxy-9,10-anthraquinol + NADP+
-
 ?
1-hydroxy-9,10-anthraquinone + NADPH
-
 Rattus norvegicus 1-hydroxy-9,10-anthraquinol + NADP+
-
 ?
2,3-diglutathionyl-1,4-naphthoquinone + NADPH
-
 Rattus norvegicus 2,3-diglutathionyl-1,4-naphthoquinol + NADP+
-
 ?
2,5-diaziridinyl-1,4-benzoquinone + NADPH
-
 Rattus norvegicus 2,5-diaziridinyl-1,4-benzoquinol + NADP+
-
 ?
2,5-dihydroxy-1,4-naphthoquinone + NADPH
-
 Rattus norvegicus 2,5-dihydroxy-1,4-naphthoquinol + NADP+
-
 ?
2,5-dimethyl-1,4-benzoquinone + NADPH
-
 Rattus norvegicus 2,5-dimethyl-1,4-benzoquinol + NADP+
-
 ?
2,5-dimethyl-3,6-diaziridinyl-1,4-benzoquinone + NADPH
-
 Rattus norvegicus 2,5-dimethyl-3,6-diaziridinyl-1,4-benzoquinol + NADP+
-
 ?
2,6-dimethyl-1,4-benzoquinone + NADPH
-
 Rattus norvegicus 2,6-dimethyl-1,4-benzoquinol + NADP+
-
 ?
2-hydroxy-1,4-naphthoquinone + NADPH
-
 Rattus norvegicus 2-hydroxy-1,4-naphthoquinol + NADP+
-
 ?
2-methyl-1,4-benzoquinone + NADPH
-
 Rattus norvegicus 2-methyl-1,4-benzoquinol + NADP+
-
 ?
2-methyl-1,4-naphthoquinone + NADPH
-
 Rattus norvegicus 2-methyl-1,4-naphthoquinol + NADp+
-
 ?
2-methyl-3-glutathionyl-5-hydroxy-1,4-naphthoquinone + NADPH
-
 Rattus norvegicus 2-methyl-3-glutathionyl-5-hydroxy-1,4-naphthoquinol + NADP+
-
 ?
2-methyl-3-hydroxy-1,4-naphthoquinone + NADPH
-
 Rattus norvegicus 2-methyl-3-hydroxy-1,4-naphthoquinol + NADP+
-
 ?
2-methyl-5-hydroxy-1,4-naphthoquinone + NADPH
-
 Rattus norvegicus 2-methyl-5-hydroxy-1,4-naphthoquinol + NADP+
-
 ?
5,8-dihydroxy-1,4-naphthoquinone + NADPH
-
 Rattus norvegicus 5,8-dihydroxy-1,4-naphthoquinol + NADP+
-
 ?
5-hydroxy-1,4-naphthoquinone + NADPH
-
 Rattus norvegicus 5-hydroxy-1,4-naphthosemiquinone + NADP+
-
 ?
9,10-anthraquinone-2,6-disulfonate + NADPH
-
 Rattus norvegicus ? + NADP+
-
 ?
9,10-anthraquinone-2-sulfonate + NADPH
-
 Rattus norvegicus ? + NADP+
-
 ?
9,10-phenanthrene quinone + NADPH
-
 Rattus norvegicus 9,10-phenanthrene quinol + NADP+
-
 ?
mitomycin C + NADPH
-
 Rattus norvegicus ? + NADP+
-
 ?
additional information plays one of the main roles in the bioactivation of quinoidal drugs Rattus norvegicus ?
-
 ?
riboflavin + NADPH
-
 Rattus norvegicus ? + NADP+
-
 ?
tetramethyl-1,4-benzoquinone + NADPH
-
 Rattus norvegicus tetramethyl-1,4-benzoquinol + NADP+
-
 ?

Synonyms

Synonyms Comment Organism
DT-diaphorase
-
 Rattus norvegicus
NAD(P)H:quinone oxidoreductase
-
 Rattus norvegicus
NQO1
-
 Rattus norvegicus

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
2.3
-
 9,10-anthraquinone-2,6-disulfonate pH 7.0 Rattus norvegicus
4.4
-
 2,3-diglutathionyl-1,4-naphthoquinone pH 7.0 Rattus norvegicus
26.3
-
 2-methyl-3-glutathionyl-5-hydroxy-1,4-naphthoquinone pH 7.0 Rattus norvegicus
52
-
 9,10-phenanthrene quinone pH 7.0 Rattus norvegicus
71
-
 5,8-Dihydroxy-1,4-naphthoquinone pH 7.0 Rattus norvegicus
222
-
 2,5-dimethyl-3,6-diaziridinyl-1,4-benzoquinone pH 7.0 Rattus norvegicus
242
-
 5-hydroxy-1,4-naphthoquinone pH 7.0 Rattus norvegicus
287
-
 2-methyl-1,4-benzoquinone pH 7.0 Rattus norvegicus
380
-
 2-methyl-1,4-naphthoquinone pH 7.0 Rattus norvegicus
431
-
 1,4-Naphthoquinone pH 7.0 Rattus norvegicus
500
-
 2-methyl-5-hydroxy-1,4-naphthoquinone pH 7.0 Rattus norvegicus
500
-
 2,5-dimethyl-1,4-benzoquinone pH 7.0 Rattus norvegicus
625
-
 2,6-dimethyl-1,4-benzoquinone pH 7.0 Rattus norvegicus
769
-
 1,4-benzoquinone pH 7.0 Rattus norvegicus
2331
-
 2,5-diaziridinyl-1,4-benzoquinone pH 7.0 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Rattus norvegicus