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Literature summary for 1.6.5.2 extracted from

  • Bauer, A.K.; Faiola, B.; Abernethy, D.J.; Marchan, R.; Pluta, L.J.; Wong, V.A.; Roberts, K.; Jaiswal, A.K.; Gonzalez, F.J.; Butterworth, B.E.; Borghoff, S.; Parkinson, H.; Everitt, J.; Recio, L.
    Genetic susceptibility to benzene-induced toxicity: role of NADPH:quinone oxidoreductase-1 (2003), Cancer Res., 63, 929-935.
    View publication on PubMed
Search for more literature for 1.6.5.2

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus lack of NQO1 in male mice increases benzene-induced hematotoxicity but not genotoxicity or the DNA damage response. NQO1 appears critical in female mice for detoxifying the metabolites of benzene responsible for genotoxicity, hematotoxicity, and induction of the DNA damage response ?
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Organism

Organism UniProt Comment Textmining
Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information lack of NQO1 in male mice increases benzene-induced hematotoxicity but not genotoxicity or the DNA damage response. NQO1 appears critical in female mice for detoxifying the metabolites of benzene responsible for genotoxicity, hematotoxicity, and induction of the DNA damage response Mus musculus ?
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 ?

Synonyms

Synonyms Comment Organism
NADPH: quinone oxidoreductase-1
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 Mus musculus
NQO1
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 Mus musculus