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Literature summary for 1.6.5.2 extracted from
- Characterization and partial purification of microsomal NAD(P)H:quinone oxidoreductases (2000), Arch. Biochem. Biophys., 375, 62-68.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | microsomal enzyme: not inhibited by dicoumarol, lapachol and p-chloromercuribenzoate | Rattus norvegicus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Rattus norvegicus | - |
- |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| microsomal enzyme, partial | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.039 | - |
activity in liver microsomes, reduction of menadione, cofactor NADPH | Rattus norvegicus |
| 0.041 | - |
activity in liver cytosol, reduction of menadione, cofactor NADH | Rattus norvegicus |
| 0.051 | - |
activity in liver cytosol, reduction of menadione, cofactor NADPH | Rattus norvegicus |
| 0.121 | - |
activity in liver cytosol, reduction of 2,6-dichlorophenolindophenol, cofactor NADPH | Rattus norvegicus |
| 0.128 | - |
activity in liver cytosol, reduction of 2,6-dichlorophenolindophenol, cofactor NADH | Rattus norvegicus |
| 0.153 | - |
activity in liver microsomes, reduction of menadione, cofactor NADH | Rattus norvegicus |
| 0.157 | - |
activity in liver microsomes, reduction of 2,6-dichlorophenolindophenol, cofactor NADPH | Rattus norvegicus |
| 0.63 | - |
activity in liver microsomes, reduction of 2,6-dichlorophenolindophenol, cofactor NADH | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2-methyl-1,4-naphthoquinone + NAD(P)H | microsomal enzyme | Rattus norvegicus | 2-methyl-1,4-naphthoquinol + NAD(P)+ | - |
? |  |
| NAD(P)H + H+ + oxidized 2,6-dichlorophenolindophenol | microsomal enzyme | Rattus norvegicus | NAD(P)+ + reduced 2,6-dichlorophenolindophenol | - |
? | |
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