Literature summary for 1.6.5.10 extracted from

Lambertucci, R.H.; Hirabara, S.M.; Silveira, L.d.o.s..R.; Levada-Pires, A.C.; Curi, R.; Pithon-Curi, T.C.
Palmitate increases superoxide production through mitochondrial electron transport chain and NADPH oxidase activity in skeletal muscle cells (2008), J. Cell. Physiol., 216, 796-804.

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Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	palmitic acid and antimycin A induce the enzyme and superoxide production	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
diphenylene iodonium	inhibition of the NADPH oxidase complex activity reduces the increase of superoxide production induced by palmitic acid	Rattus norvegicus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytoplasm	NADPH oxidase complex consists of membrane and cytosolic subunits	Rattus norvegicus	5737	-
membrane	NADPH oxidase complex consists of membrane and cytosolic subunits. The gp91phox and p22phox are integral membrane proteins that form a heterodimeric flavocytochrome b558, the catalytic core of the enzyme	Rattus norvegicus	16020	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
NADPH + H+ + cytochrome c	Rattus norvegicus	-	NADP+ + reduced cytochrome c	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	Wistar rats	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
skeletal muscle cell	soleus, gastrocnemius, and quadriceps muscles, primary culture of cells	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
NADPH + H+ + cytochrome c	-	Rattus norvegicus	NADP+ + reduced cytochrome c	-	?

Subunits

Subunits	Comment	Organism
More	NADPH oxidase complex consists of membrane and cytosolic subunits. The gp91phox and p22phox are integral membrane proteins that form a heterodimeric flavocytochrome b558, the catalytic core of the enzyme	Rattus norvegicus

Synonyms

Synonyms	Comment	Organism
NADPH oxidase	-	Rattus norvegicus

Cofactor

Cofactor	Comment	Organism	Structure
cytochrome b558	gp91phox and p22phox are integral membrane proteins that form a heterodimeric flavocytochrome b558, the catalytic core of the enzyme	Rattus norvegicus
cytochrome c	-	Rattus norvegicus

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Release 2023.1 (January 2023)