Inhibitors | Comment | Organism | Structure |
---|---|---|---|
CuSO4 | 0.2 mM, 97% inhibition | Giardia intestinalis | |
H2O2 | 0.5 mM, 50% inhibition | Giardia intestinalis | |
HgCl2 | 0.5 mM, 80% inhibition | Giardia intestinalis | |
additional information | no inhibition by EDTA | Giardia intestinalis | |
p-chloromercuribenzoate | 0.05 mM, complete inhibition | Giardia intestinalis | |
Quinacrine | 1 mM, 73% inhibition | Giardia intestinalis | |
Quinine | 0.2 mM, 50% inhibition | Giardia intestinalis | |
ZnSO4 | 0.1 mM, 98% inhibition | Giardia intestinalis |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0042 | - |
NADH | pH 7.8, 22°C | Giardia intestinalis | |
0.016 | - |
NADPH | pH 7.8, 22°C | Giardia intestinalis |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
additional information | activity is not enhanced by the addition of various heavy metals which suggests that the enzyme does not contain any metal ions as co-factors | Giardia intestinalis |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
45116 | - |
1 * 45116, calculated from sequence | Giardia intestinalis |
46000 | - |
1 * 46000, SDS-PAGE | Giardia intestinalis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
2 NADPH + 2 H+ + O2 | Giardia intestinalis | the enzyme may be involved in maintenance of an optimum intracellular redox ratio | 2 NADP+ + 2 H2O | - |
? | |
2 NADPH + 2 H+ + O2 | Giardia intestinalis BRIS/83/HEPU/106 | the enzyme may be involved in maintenance of an optimum intracellular redox ratio | 2 NADP+ + 2 H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Giardia intestinalis | Q7M4I9 | - |
- |
Giardia intestinalis BRIS/83/HEPU/106 | Q7M4I9 | - |
- |
Purification (Comment) | Organism |
---|---|
- |
Giardia intestinalis |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
trophozoite | - |
Giardia intestinalis | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2 NADH + H+ + O2 | NADPH is more efficient as electron donor compared to NADH | Giardia intestinalis | NAD+ + 2 H2O | - |
? | |
2 NADH + H+ + O2 | NADPH is more efficient as electron donor compared to NADH | Giardia intestinalis BRIS/83/HEPU/106 | NAD+ + 2 H2O | - |
? | |
2 NADPH + 2 H+ + O2 | the enzyme may be involved in maintenance of an optimum intracellular redox ratio | Giardia intestinalis | 2 NADP+ + 2 H2O | - |
? | |
2 NADPH + 2 H+ + O2 | O2 is the most effective electron acceptor, NADH or NADPH are not oxidized anaerobically | Giardia intestinalis | 2 NADP+ + 2 H2O | - |
? | |
2 NADPH + 2 H+ + O2 | the enzyme may be involved in maintenance of an optimum intracellular redox ratio | Giardia intestinalis BRIS/83/HEPU/106 | 2 NADP+ + 2 H2O | - |
? | |
2 NADPH + 2 H+ + O2 | O2 is the most effective electron acceptor, NADH or NADPH are not oxidized anaerobically | Giardia intestinalis BRIS/83/HEPU/106 | 2 NADP+ + 2 H2O | - |
? | |
additional information | cytochrome c is not reduced under any assay conditions used | Giardia intestinalis | ? | - |
? | |
additional information | cytochrome c is not reduced under any assay conditions used | Giardia intestinalis BRIS/83/HEPU/106 | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
monomer | 1 * 46000, SDS-PAGE | Giardia intestinalis |
monomer | 1 * 45116, calculated from sequence | Giardia intestinalis |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.8 | - |
- |
Giardia intestinalis |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
7 | 9 | active over the range pH 7-9 | Giardia intestinalis |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | FAD is noncoveltly bound, 1 mol of FAD per mol of polypeptide | Giardia intestinalis | |
NADH | NADPH is more efficient as electron donor compared to NADH | Giardia intestinalis | |
NADPH | NADPH is more efficient as electron donor compared to NADH | Giardia intestinalis |
General Information | Comment | Organism |
---|---|---|
physiological function | the enzyme may be involved in maintenance of an optimum intracellular redox ratio | Giardia intestinalis |