Inhibitors | Comment | Organism | Structure |
---|---|---|---|
apocynin | - |
Oryctolagus cuniculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Oryctolagus cuniculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
forebrain | - |
Oryctolagus cuniculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
NADPH + H+ + O2 | - |
Oryctolagus cuniculus | NADP+ + H2O2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
NADPH oxidase | - |
Oryctolagus cuniculus |
Organism | Comment | Expression |
---|---|---|
Oryctolagus cuniculus | NADPH oxidase activity is significantly increased in both the periventricular region and cortex of pups with intraventricular hemorrhage than glycerol- and saline-treated controls at 6h age, and remains substantially elevated at 24h postnatal age | up |
General Information | Comment | Organism |
---|---|---|
malfunction | NAD(P)H oxidase inhibition by apocynin might suppress reactive oxygen species production and confer neuroprotection in premature infants with intraventricular hemorrhage | Oryctolagus cuniculus |
physiological function | germinal matrix hemorrhage-intraventricular hemorrhage, by induction of NAD(P)H oxidases, may cause oxidative/nitrosative stress contributing to brain injuries. Activation of NAD(P)H oxidase is the predominant mechanism of free-radical generation in pups with intraventricular hemorrhage | Oryctolagus cuniculus |