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Literature summary for 1.6.3.1 extracted from

  • Block, K.; Gorin, Y.; Hoover, P.; Williams, P.; Chelmicki, T.; Clark, R.A.; Yoneda, T.; Abboud, H.E.
    NAD(P)H oxidases regulate HIF-2alpha protein expression (2007), J. Biol. Chem., 282, 8019-8026.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
additional information in cells deficient for von Hippel-Lindau tumor suppressor gene, protein levels of subunit p22phox, of isoform Nox4 and NADPH-dependent superoxide levels are increased. Down-regulation of isoforms Nox1, Nox4, and p22phox expression by small interfering RNA decreases hypoxia-inducible factor 2alpha# protein expression and inhibits Akt and 4E-BP1 phosphorylation Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
diphenylene iodonium inhibition of NADPH oxidase. In cells deficient for von Hippel-Lindau tumor suppressor gene, presence of diphenyleneiodonium decreases the expression of hypoxia-inducible factor 2alpha Homo sapiens
diphenylene iodonium significantly inhibits RCC 786-O tumor formation in athymic mice Mus musculus

Organism

Organism UniProt Comment Textmining
Homo sapiens
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Mus musculus
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Source Tissue

Source Tissue Comment Organism Textmining
ACHN cell
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Homo sapiens
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HK-2 cell
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Homo sapiens
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RCC 786-O cell deficient for von Hippel-Lindau tumor suppressor gene Homo sapiens
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Subunits

Subunits Comment Organism
More subunit p22phox co-immunoprecipitates with Hippel-Lindau tumor suppressor in vivo and is target of ubiquitination Homo sapiens