Literature summary for 1.6.3.1 extracted from

Si, J.; Fu, X.; Behar, J.; Wands, J.; Beer, D.G.; Souza, R.F.; Spechler, S.J.; Lambeth, D.; Cao, W.
NADPH oxidase NOX5-S mediates acid-induced cyclooxygenase-2 expression via activation of NF-kappaB in Barretts esophageal adenocarcinoma cells (2007), J. Biol. Chem., 282, 16244-16255.

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Protein Variants

Protein Variants	Comment	Organism
additional information	knockdown of isoform NOX5-S or NF-kappaB1 p50 by their small interfering RNA significantly inhibits acid-induced cyclooxygenase COX2 expression and prostaglandin PGE2 production in SEG-1 cells. In a Barrett's cell line overexpressing isoform NOX5-S, inhibitor of kappaB is significantly reduced, and luciferase activity increased when these Barrett' s cells are transfected with a plasmid carrying NF-kappaB fused to luciferase. Overexpression of NOX5-S in Barretts cells significantly increases H2O2 production,cyclooxygenase COX2 expression, PGE2 production, and thymidine incorporation	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	isoform Nox5-S	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
muscle	muscle biopsies of patients with Barrett's esophagus	Homo sapiens	-
SEG-1 cell	Barretts esophageal adenocarcinoma cells	Homo sapiens	-

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Release 2023.1 (January 2023)