Literature summary for 1.6.3.1 extracted from

Sheu, M.L.; Chiang, C.K.; Tsai, K.S.; Ho, F.M.; Weng, T.I.; Wu, H.Y.; Liu, S.H.
Inhibition of NADPH oxidase-related oxidative stress-triggered signaling by honokiol suppresses high glucose-induced human endothelial cell apoptosis (2008), Free Radic. Biol. Med., 44, 2043-2050.

Search for more literature for 1.6.3.1

Inhibitors

Inhibitors	Comment	Organism	Structure
honokiol	submicromolar concentrations of honokiol suppress the increases of NADPH oxidase activity, Rac-1 phosphorylation, p22phox protein expression, and reactive oxygen species production in high glucose-stimulated HUVEC cells. Honokiol also suppresses high glucose-induced cyclooxygenase-2 upregulation and prostaglandin E2 production. Honokiol can reduce increased caspase-3 activity and the subsequent apoptosis and cell death triggered by high glucose medium	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HUVEC cell	-	Homo sapiens	-

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)