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Literature summary for 1.6.3.1 extracted from

  • Becker, S.; Reinehr, R.; Graf, D.; vom Dahl, S.; Haeussinger, D.
    Hydrophobic bile salts induce hepatocyte shrinkage via NADPH oxidase activation (2007), Cell. Physiol. Biochem., 19, 89-98.
    View publication on PubMed

Application

Application Comment Organism
medicine hydrophobic, proapoptotic bile salts induce hepatocyte shrinkage largely through NADPH oxidase-derived oxidative stress. Because cell shrinkage in turn activates NADPH oxidase, which blunts cell volume recovery, a vicious cycle ensues between oxidative stress and cell shrinkage, which propagates CD95 activation and may finally lead to apoptosis Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
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Source Tissue

Source Tissue Comment Organism Textmining
hepatocyte taurolithocholylsulfate induces shrinkage in wild-type, but not in subunit p47phox-deficient hepatocytes. Hepatocytes from subunit p47phox knock-out mice are resistant towards taurolithocholylsulfate-induced apoptosis and fail to activate the CD95 system Mus musculus
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