Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.6.3.1 extracted from

  • An, S.J.; Boyd, R.; Zhu, M.; Chapman, A.; Pimentel, D.R.; Wang, H.D.
    NADPH oxidase mediates angiotensin II-induced endothelin-1 expression in vascular adventitial fibroblasts (2007), Cardiovasc. Res., 75, 702-709.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
additional information deletion of subunit gp91phox attenuates angiotensin II-induced responses Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
apocynin treatment significantly decreases angiotensin II-induced endothelin-1 RNA and peptide expression, superoxide production as well as collagen expression Mus musculus
diphenyleneiodonium treatment significantly decreases angiotensin II-induced endothelin-1 RNA and peptide expression, superoxide production as well as collagen expression Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus angiotensin II-evoked expression of endothelin-1 in adventitial fibroblasts is mediated, at least in part, by NADPH oxidase. This mechanism stimulates collagen expression thereby implicating the adventitia as a potential contributor to the vascular pathophysiology associated with oxidative stress and vascular remodeling ?
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
aorta
-
Mus musculus
-
fibroblast primary culture of adventitial fibroblast Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information angiotensin II-evoked expression of endothelin-1 in adventitial fibroblasts is mediated, at least in part, by NADPH oxidase. This mechanism stimulates collagen expression thereby implicating the adventitia as a potential contributor to the vascular pathophysiology associated with oxidative stress and vascular remodeling Mus musculus ?
-
?