Literature summary for 1.6.3.1 extracted from

Ostanin, D.V.; Barlow, S.; Shukla, D.; Grisham, M.B.
NADPH oxidase but not myeloperoxidase protects lymphopenic mice from spontaneous infections (2007), Biochem. Biophys. Res. Commun., 355, 801-806.

Search for more literature for 1.6.3.1

Application

Application	Comment	Organism
additional information	NADPH oxidase but not myeloperoxidase is required for host defense in lymphopenic mice. Lymphocytes and NADPH oxidase may compensate for each other's deficiency in providing resistance to spontaneous bacterial infections	Mus musculus

Protein Variants

Protein Variants	Comment	Organism
additional information	neither mice lacking subunit gp91, lacking myeloperoxidase, nor lymphocyte-deficient recombinase activating gene-1 ko mice develop spontaneous infections when raised under specific pathogen-free conditions and all mice have life spans similar to wild-type animals. Subunit gp91/recombinase activating gene-1 double-deficient but not myeloperoxidase/recombinase activating gene-1 double-deficient mice develop spontaneous multi-organ bacterial and fungal infections early in life and live only a few months. Infections in the gp91/recombinase activating gene-1 double-deficient mice are characterized by granulomatous inflammation of the skin, liver, heart, brain, kidney, and lung. Oyster glycogen-elicited polymorphonuclear neutrophils and macrophages obtained from gp91 ko and gp91/recombinase activating gene-1 double-deficient mice have no detectable NADPH oxidase activity whereas wild-type, recombinase activating gene-1 ko, and myeloperoxidase/recombinase activating gene-1 polymorphonuclear neutrophils and macrophages produce large and similar amounts of superoxide in response to phorbol myristate acetate	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

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Release 2023.1 (January 2023)