Literature summary for 1.6.3.1 extracted from

Chandramohan, G.; Bai, Y.; Norris, K.; Rodriguez-Iturbe, B.; Vaziri, N.D.
Effects of dietary salt on intrarenal angiotensin system, NAD(P)H oxidase, COX-2, MCP-1 and PAI-1 expressions and NF-kappaB activity in salt-sensitive and -resistant rat kidneys (2008), Am. J. Nephrol., 28, 158-167.

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Application

Application	Comment	Organism
medicine	salt sensitivity in the salt-sensitive rat is associated with upregulations of the intrarenal angiotensin system, reactive oxygen species-generating and proinflammatory/profibrotic proteins and an inability to raise antioxidant enzymes and maximally suppress plasma renin activity in response to high salt intake	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	DAHl salt-sensitive and -resistant rats	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
kidney	salt-sensitive rats consuming a low-salt diet exhibit significant increases in AT 1 receptor, cyclooxygenase-2, plasminogen activator inhibitor PAI and phospho-I kappaB in the kidney as compared to those found in salt-resistant rats. The high-salt diet results in severe hypertension and proteinuria in salt-sensitive but not salt-resistant rats, and marked elevations of renal tissue monocyte chemoattractant protein 1, p22phox, NADPH oxidase subunit 4, angiotensin-II-positive cell count, infiltrating T cells and macrophages and further increases in AT 1 receptor, cyclooxygenase-2, PAI-1 and phospho-IkappaB in the salt-sensitive group	Rattus norvegicus	-

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Release 2023.1 (January 2023)