Literature summary for 1.6.3.1 extracted from

Djordjevic, T.; Pogrebniak, A.; BelAiba, R.S.; Bonello, S.; Wotzlaw, C.; Acker, H.; Hess, J.; Goerlach, A.
The expression of the NADPH oxidase subunit p22phox is regulated by a redox-sensitive pathway in endothelial cells (2005), Free Radic. Biol. Med., 38, 616-630.

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Activating Compound

Activating Compound	Comment	Organism	Structure
thrombin	administration of thrombin to endothelial cells leads to upregulation of enzyme subunit p22phox accompanied by a delayed increase in generation of reactive oxygen species and enhanced proliferation. Existence of a positive feedback mechanism, whereby reactive oxygen species lead to elevated levels of p22phox and thus, sustained generation of reactive oxygen species as is observed in endothelial dysfunction	Homo sapiens

Application

Application	Comment	Organism
medicine	administration of thrombin to endothelial cells leads to upregulation of enzyme subunit p22phox accompanied by a delayed increase in generation of reactive oxygen species and enhanced proliferation. Existence of a positive feedback mechanism, whereby reactive oxygen species lead to elevated levels of p22phox and thus, sustained generation of reactive oxygen species as is observed in endothelial dysfunction	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
EAhy 926 cell	endothelial hybridoma cell line	Homo sapiens	-

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Release 2023.1 (January 2023)