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Literature summary for 1.6.2.4 extracted from

  • Gocek, E.; Marchwicka, A.; Bujko, K.; Marcinkowska, E.
    NADPH-cytochrome P450 reductase is regulated by all-trans retinoic acid and by 1,25-dihydroxyvitamin D3 in human acute myeloid leukemia cells (2014), PLoS ONE, 9, e91752 .
    View publication on PubMedView publication on EuropePMC

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
Homo sapiens 16020
-
mitochondrion
-
Homo sapiens 5739
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
acute myeloid leukemia cell
-
Homo sapiens
-
HL-60 cell
-
Homo sapiens
-
KG-1 cell
-
Homo sapiens
-
NB-4 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NADPH + H+ + ferricytochrome c
-
Homo sapiens NADP+ + ferrocytochrome c
-
?

Subunits

Subunits Comment Organism
? x * 80000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
NADPH-cytochrome P450 reductase
-
Homo sapiens
POR
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
FAD
-
Homo sapiens
FMN
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens the enzyme in acute myeloid leukemia cells is upregulated by all-trans-retinoic acid and by 1,25-dihydroxyvitamin D3 at the level of mRNA and protein up