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Literature summary for 1.6.2.4 extracted from

  • Lee, C.A.; Kadwell, S.H.; Kost, T.A.; Serabjit-Singh, C.J.
    CYP3A4 expressed by insect cells infected with a recombinant baculovirus containing both CYP3A4 and human NADPH-cytochrome P450 reductase is catalytically similar to human liver microsomal CYP3A4 (1995), Arch. Biochem. Biophys., 319, 157-167.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
coexpression with CYP3A4 in Spodoptera frugiperda and Trichoplusia ni cell lines Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Homo sapiens
-
-
microsome
-
Trichoplusia ni
-
-
microsome
-
Spodoptera frugiperda
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Spodoptera frugiperda
-
-
-
Trichoplusia ni
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.0128
-
endogenous enzyme Spodoptera frugiperda
0.0173
-
endogenous enzyme Trichoplusia ni
0.225 0.38 endogenous enzyme Homo sapiens
1.696
-
recombinant enzyme coexpressed with CYP3A4 in Spodoptera frugiperda cell lines Homo sapiens
3.904
-
recombinant enzyme coexpressed with CYP3A4 in Trichoplusia ni cell lines Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 ferricytochrome c + NADPH
-
Homo sapiens 2 ferrocytochrome c + NADP+ + H+
-
?
2 ferricytochrome c + NADPH
-
Trichoplusia ni 2 ferrocytochrome c + NADP+ + H+
-
?
2 ferricytochrome c + NADPH
-
Spodoptera frugiperda 2 ferrocytochrome c + NADP+ + H+
-
?
additional information coexpressed with CYP3A4 in insect cell lines, testosterone 6-beta-hydroxylase activity Homo sapiens ?
-
?