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Literature summary for 1.6.2.2 extracted from
- Human cytochrome b5 reductase Structure, function, and potential applications (2014), Crit. Rev. Biotechnol., 34, 134-143 .
No PubMed abstract available
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Homo sapiens | - |
- |
| microsome | - |
Bos taurus | - |
- |
| soluble | - |
Homo sapiens | - |
- |
| soluble | - |
Bos taurus | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| NADH + ferricytochrome b5 | Homo sapiens | - |
NAD+ + H+ + ferrocytochrome b5 | - |
? |  |
| NADH + ferricytochrome b5 | Arabidopsis thaliana | - |
NAD+ + H+ + ferrocytochrome b5 | - |
? | |
| NADH + ferricytochrome b5 | Bos taurus | - |
NAD+ + H+ + ferrocytochrome b5 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Arabidopsis thaliana | A0A178US77 | - |
- |
| Bos taurus | P07514 | - |
- |
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| DEAE-cellulose column chromatography, DEAE-Sepharose column chromatography, DEAE-Trisacryl column chromatography, agarose-hexane-NAD column chromatography, ADP-agarose column chromatography, 5'-AMP-Sepharose column chromatography, blue-Ultrogel column chromatography, octylamino-Sepharose column chromatography, blue 2-Sepharose column chromatography, Sephadex G-100 gel filtration, 5'-ADP-hexane-agarose column chromatography, hydroxyapatite column chromatography, CM-Sephadex gel filtration, or NAD agarose column chromatography | Homo sapiens |
| DEAE-cellulose column chromatography, DEAE-Sepharose column chromatography, DEAE-Trisacryl column chromatography, agarose-hexane-NAD column chromatography, ADP-agarose column chromatography, 5'-AMP-Sepharose column chromatography, blue-Ultrogel column chromatography, octylamino-Sepharose column chromatography, blue 2-Sepharose column chromatography, Sephadex G-100 gel filtration, 5'-ADP-hexane-agarose column chromatography, hydroxyapatite column chromatography, CM-Sephadex gel filtration, or NAD agarose column chromatography | Arabidopsis thaliana |
| DEAE-cellulose column chromatography, DEAE-Sepharose column chromatography, DEAE-Trisacryl column chromatography, agarose-hexane-NAD column chromatography, ADP-agarose column chromatography, 5'-AMP-Sepharose column chromatography, blue-Ultrogel column chromatography, octylamino-Sepharose column chromatography, blue 2-Sepharose column chromatography, Sephadex G-100 gel filtration, 5'-ADP-hexane-agarose column chromatography, hydroxyapatite column chromatography, CM-Sephadex gel filtration, or NAD agarose column chromatography | Bos taurus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| erythrocyte | - |
Homo sapiens | - |
| erythrocyte | - |
Bos taurus | - |
| liver | - |
Homo sapiens | - |
| liver | - |
Bos taurus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| NADH + ferricyanide | - |
Homo sapiens | NAD+ + H+ + ferrocyanide | - |
? | |
| NADH + ferricyanide | - |
Arabidopsis thaliana | NAD+ + H+ + ferrocyanide | - |
? | |
| NADH + ferricyanide | - |
Bos taurus | NAD+ + H+ + ferrocyanide | - |
? | |
| NADH + ferricytochrome b5 | - |
Homo sapiens | NAD+ + H+ + ferrocytochrome b5 | - |
? | |
| NADH + ferricytochrome b5 | - |
Arabidopsis thaliana | NAD+ + H+ + ferrocytochrome b5 | - |
? | |
| NADH + ferricytochrome b5 | - |
Bos taurus | NAD+ + H+ + ferrocytochrome b5 | - |
? | |
| NADH + oxidized 2,6-dichlorophenolindophenol | - |
Homo sapiens | NAD+ + H+ + reduced 2,6-dichlorophenolindophenol | - |
? | |
| NADH + oxidized 2,6-dichlorophenolindophenol | - |
Arabidopsis thaliana | NAD+ + H+ + reduced 2,6-dichlorophenolindophenol | - |
? | |
| NADH + oxidized 2,6-dichlorophenolindophenol | - |
Bos taurus | NAD+ + H+ + reduced 2,6-dichlorophenolindophenol | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CyB5R | - |
Homo sapiens |
| CyB5R | - |
Arabidopsis thaliana |
| CyB5R | - |
Bos taurus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| FAD | - |
Homo sapiens | |
| FAD | - |
Arabidopsis thaliana | |
| FAD | - |
Bos taurus | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | autosomal cytochrome b5 reductase gene deficiency manifests with the accumulation of oxidized Fe3+ and recessive congenital methemoglobinemia in humans | Homo sapiens |
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Release 2023.1 (January 2023)
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