BRENDA - Enzyme Database show
show all sequences of 1.6.1.3

Hymenolepis diminuta: catalysis of transmembrane proton translocation by mitochondrial NADPH->NAD transhydrogenase

Mercer, N.A.; McKelvey, J.R.; Fioravanti, C.F.; Exp. Parasitol. 91, 52-58 (1999)

Data extracted from this reference:

Activating Compound
Activating Compound
Commentary
Organism
Structure
carbonyl cyanide 3-chlorophenylhydrazone
-
Hymenolepis diminuta
carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone
-
Hymenolepis diminuta
niclosamide
-
Hymenolepis diminuta
Inhibitors
Inhibitors
Commentary
Organism
Structure
1,3-dicyclohexyl-1,3-diazapropa-1,2-diene
-
Hymenolepis diminuta
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
mitochondrial inner membrane
-
Hymenolepis diminuta
5743
-
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
NADPH + NAD+
Hymenolepis diminuta
-
NADP+ + NADH
-
-
r
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Hymenolepis diminuta
-
-
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
NADPH + NAD+
-
724928
Hymenolepis diminuta
NADP+ + NADH
-
-
-
r
Cofactor
Cofactor
Commentary
Organism
Structure
NADPH
-
Hymenolepis diminuta
Activating Compound (protein specific)
Activating Compound
Commentary
Organism
Structure
carbonyl cyanide 3-chlorophenylhydrazone
-
Hymenolepis diminuta
carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone
-
Hymenolepis diminuta
niclosamide
-
Hymenolepis diminuta
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
NADPH
-
Hymenolepis diminuta
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
1,3-dicyclohexyl-1,3-diazapropa-1,2-diene
-
Hymenolepis diminuta
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
mitochondrial inner membrane
-
Hymenolepis diminuta
5743
-
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
NADPH + NAD+
Hymenolepis diminuta
-
NADP+ + NADH
-
-
r
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
NADPH + NAD+
-
724928
Hymenolepis diminuta
NADP+ + NADH
-
-
-
r
General Information
General Information
Commentary
Organism
physiological function
the enzyme of adult Hymenolepis diminuta physiologically couples matrix-localized, NADP-specific malic enzyme with NADH-dependent anaerobic electron transport. The enzyme acts in the translocation of protons from the matrix to the intermembrane space mitochondrial compartment
Hymenolepis diminuta
General Information (protein specific)
General Information
Commentary
Organism
physiological function
the enzyme of adult Hymenolepis diminuta physiologically couples matrix-localized, NADP-specific malic enzyme with NADH-dependent anaerobic electron transport. The enzyme acts in the translocation of protons from the matrix to the intermembrane space mitochondrial compartment
Hymenolepis diminuta
Other publictions for EC 1.6.1.3
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
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Nikel
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741856
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Pyruvate dehydrogenase comple ...
Mus musculus
Biochem. J.
467
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392667
Bergkvist
Interactions of the NADP(H)-bi ...
Escherichia coli
Biochemistry
39
12595-12605
2000
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4
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724928
Mercer
Hymenolepis diminuta: catalysi ...
Hymenolepis diminuta
Exp. Parasitol.
91
52-58
1999
3
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1
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3
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1
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1
1
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723924
Chen
Malate metabolism by Desulfovi ...
Desulfovibrio gigas
Anaerobe
1
227-235
1995
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724104
Vercesi
The participation of NADP, the ...
Rattus norvegicus
Arch. Biochem. Biophys.
252
171-178
1987
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1
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724795
McKelvey
Coupling of malic enzyme and N ...
Hymenolepis diminuta
Comp. Biochem. Physiol. B
77
737-742
1984
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1
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1
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1
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392576
Voordouw
Pyridine nucleotide transhydro ...
Azotobacter vinelandii, Azotobacter vinelandii ATCC 478
Eur. J. Biochem.
111
347-355
1980
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1
2
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2
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1
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2
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722576
Keister
Pyridine nucleotide transhydro ...
Spinacia oleracea
J. Biol. Chem.
235
2989-2996
1960
-
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6
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1
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1
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1
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1
6
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1
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2
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1
1
1
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6
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1
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1
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1
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6
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1
1
1
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