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Literature summary for 1.5.99.B2 extracted from
- Overexpression of proline oxidase induces proline-dependent and mitochondria-mediated apoptosis (2007), Mol. Cell. Biochem., 295, 85-92.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| L-proline | in the presence of L-proline, high POX activity is sufficient to induce mitochondria-mediated apoptosis | Homo sapiens |  |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in DLD-1.POX cells | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | - |
Homo sapiens | 5739 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| colorectal cancer cell | - |
Homo sapiens | - |
| DLD-1 cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-proline + cytochrome c + H2O | - |
Homo sapiens | (S)-1-pyrroline-5-carboxylate + reduced cytochrome c | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| POX | - |
Homo sapiens |
| PRODH | - |
Homo sapiens |
| proline dehydrogenase | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| FAD | - |
Homo sapiens | |
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Release 2023.1 (January 2023)
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