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Literature summary for 1.5.99.B2 extracted from

  • Tritsch, D.; Mawlawi, H.; Biellmann, J.F.
    Mechanism-based inhibition of proline dehydrogenase by proline analogues (1993), Biochim. Biophys. Acta, 1202, 77-81.
    View publication on PubMed
Search for more literature for 1.5.99.B2

Inhibitors

Inhibitors Comment Organism Structure
4-methylene-L-proline no effect Drosophila melanogaster
4-methylene-L-proline lethal to the flies Glossina morsitans
4-methylene-L-proline pseudo-first-order kinetics Rattus norvegicus
Lactate
-
 Rattus norvegicus
pyrrole-2-carboxylic acid noncompetitive Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2 6 L-proline depends on assay method Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Rattus norvegicus 5739
-

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster
-
-
-
Glossina morsitans
-
 tsetse fly
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-methylene-L-proline + acceptor + H2O
-
 Rattus norvegicus DELTA1-pyrroline-3-methylene-5-carboxylic acid + reduced acceptor
-
 ?
L-proline + acceptor + H2O
-
 Drosophila melanogaster (S)-1-pyrroline-5-carboxylate + reduced acceptor
-
 ?
L-proline + acceptor + H2O
-
 Rattus norvegicus (S)-1-pyrroline-5-carboxylate + reduced acceptor
-
 ?
L-proline + acceptor + H2O
-
 Glossina morsitans (S)-1-pyrroline-5-carboxylate + reduced acceptor
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.9
-
 D,L-lactate
-
 Rattus norvegicus