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Literature summary for 1.5.99.12 extracted from

  • Zatloukal, M.; Gemrotova, M.; Dolezal, K.; Havlicek, L.; Spichal, L.; Strnad, M.
    Novel potent inhibitors of A. thaliana cytokinin oxidase/dehydrogenase (2008), Bioorg. Med. Chem., 16, 9268-9275.
    View publication on PubMed
Search for more literature for 1.5.99.12

Cloned(Commentary)

Cloned (Comment) Organism
heterologously expressed in Saccharomyces cerevisiae Arabidopsis thaliana

Inhibitors

Inhibitors Comment Organism Structure
2-amino-6-(3-methoxyanilino)purine
-
 Arabidopsis thaliana
2-chloro-6-(2-hydroxyanilino)purine
-
 Arabidopsis thaliana
2-chloro-6-(2-methoxyanilino)purine
-
 Arabidopsis thaliana
2-chloro-6-(3-chloroanilino)purine
-
 Arabidopsis thaliana
2-chloro-6-(3-fluoroanilino)purine
-
 Arabidopsis thaliana
2-chloro-6-(3-hydroxyanilino)purine
-
 Arabidopsis thaliana
2-chloro-6-(3-methoxyanilino)-9-isopropylpurine
-
 Arabidopsis thaliana
2-chloro-6-(3-methoxyanilino)-9-methylpurine
-
 Arabidopsis thaliana
2-chloro-6-(3-methoxyanilino)purine
-
 Arabidopsis thaliana
2-chloro-6-(4-chloroanilino)purine
-
 Arabidopsis thaliana
2-chloro-6-(4-fluoroanilino)purine
-
 Arabidopsis thaliana
2-chloro-6-(4-hydroxyanilino)purine
-
 Arabidopsis thaliana
2-chloro-6-(4-methoxyanilino)purine
-
 Arabidopsis thaliana
2-chloro-6-anilinopurine
-
 Arabidopsis thaliana
2-fluoro-6-(3-methoxyanilino)purine
-
 Arabidopsis thaliana
2-methylthio-6-(3-methoxyanilino)purine
-
 Arabidopsis thaliana
2-nitro-6-(3-methoxyanilino)purine
-
 Arabidopsis thaliana
6-(3-methoxyanilino)purine
-
 Arabidopsis thaliana
thidiazuron
-
 Arabidopsis thaliana

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana
-
-
-

Synonyms

Synonyms Comment Organism
cytokinin oxidase/dehydrogenase
-
 Arabidopsis thaliana

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
additional information
-
 IC50-values above 0.1 mM for 2-chloro-6-(2-hydroxyanilino)purine, 2-chloro-6-(4-hydroxyanilino)purine, 2-chloro-6-(2-methoxyanilino)purine, 2-chloro-6-(4-methoxyanilino)purine, 2-methylthio-6-(3-methoxyanilino)purine and 2-chloro-6-(3-methoxyanilino)-9-isopropylpurine, no inhibition observed for 6-anilinopurine and trans-zeatin Arabidopsis thaliana additional information
0.001
-
-
 Arabidopsis thaliana 2-fluoro-6-(3-methoxyanilino)purine
0.0019
-
-
 Arabidopsis thaliana 2-chloro-6-(3-methoxyanilino)purine
0.00375
-
-
 Arabidopsis thaliana 2-chloro-6-(3-hydroxyanilino)purine
0.0039
-
-
 Arabidopsis thaliana 2-chloro-6-(3-chloroanilino)purine
0.0075
-
-
 Arabidopsis thaliana 2-chloro-6-(3-fluoroanilino)purine
0.0124
-
-
 Arabidopsis thaliana 6-(3-methoxyanilino)purine
0.014
-
-
 Arabidopsis thaliana 2-nitro-6-(3-methoxyanilino)purine
0.0254
-
-
 Arabidopsis thaliana 2-chloro-6-(4-chloroanilino)purine
0.027
-
-
 Arabidopsis thaliana 2-amino-6-(3-methoxyanilino)purine
0.029
-
-
 Arabidopsis thaliana thidiazuron
0.05
-
-
 Arabidopsis thaliana 2-chloro-6-(4-fluoroanilino)purine
0.061
-
-
 Arabidopsis thaliana 2-chloro-6-(3-methoxyanilino)-9-methylpurine
0.08
-
-
 Arabidopsis thaliana 2-chloro-6-anilinopurine